TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression

The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor-mediated signaling upon viral replication will be...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39276
Hauptverfasser:	Park, Sun O, Kumar, Mukesh, Gupta, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Biomarkers Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Cancer Cell signaling Cytokines Deoxyribonucleic acid DNA Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Genomes Growth factors Heavy metals Heme Hep G2 Cells Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - physiology Hepatocytes Hepatocytes - metabolism Hepatocytes - virology Hepcidin Host-Pathogen Interactions Humans Infections Interferon Iron Iron - metabolism Iron - pharmacology Kinases Liver Lymphocytes B Medicine MicroRNAs MicroRNAs - genetics miRNA Pathways Proteins Replication Ribonucleic acid RNA Rodents Signal transduction Signal Transduction - drug effects Signaling Smad protein Smad Proteins - metabolism Smad4 protein Studies Transcription factors Transcription, Genetic Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Virus Replication - drug effects Viruses
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