Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo

Betahistine is a histamine H(1)-receptor agonist and H(3)-receptor antagonist that is administered to treat Menière's disease. Despite widespread use, its pharmacological mode of action has not been entirely elucidated. This study investigated the effect of betahistine on guinea pigs at dosages...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39086
Hauptverfasser:	Ihler, Fritz, Bertlich, Mattis, Sharaf, Kariem, Strieth, Sebastian, Strupp, Michael, Canis, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial Pressure - drug effects Betahistine - pharmacology Biology Blood Blood flow Blood pressure Blood pressure measurement Body weight Capillaries Capillaries - drug effects Circulatory system Clinical trials Cochlea Cochlea - drug effects Dosage Dose-Response Relationship, Drug Drug dosages Experiments Female Flow Fluorescence Fluorescence microscopy Guinea Pigs Histamine Hospitals In vivo methods and tests Lasers Medical treatment Medicine Meniere's disease Microscopy Mode of action Otolaryngology Pharmacology Plasma Pressure measurement Pressure measurements Rodents Sodium chloride Stria vascularis Studies Surgery Variance analysis Vasodilator Agents - pharmacology Veins & arteries Vertigo
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