Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing

Pterygium is a lesion of the eye surface which involves cell proliferation, migration, angiogenesis, fibrosis, and extracellular matrix remodelling. Surgery is the only approved method to treat this disorder, but high recurrence rates are common. Recently, it has been shown in a mouse model that tre...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39359
Hauptverfasser:	Larráyoz, Ignacio M, de Luis, Alberto, Rúa, Oscar, Velilla, Sara, Cabello, Juan, Martínez, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Antibiotics Apoptosis Bioinformatics Biology Biomedical research Cell culture Cell cycle Cell growth Cell proliferation Cell surface Chromosomes Clinical trials Cluster Analysis Colorectal cancer Cornea Cytokines Data acquisition Doxycycline Doxycycline - administration & dosage Doxycycline - pharmacology Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Enzyme-linked immunosorbent assay Epidermal growth factor Extracellular matrix Eye Female Females Fibroblasts Fibrosis Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene sequencing Genes Genes, Mitochondrial Growth factors High-Throughput Nucleotide Sequencing Humans Identification methods Integrins Lesions Liver cancer Male Medical research Medicine Middle Aged Mitochondria Oncology Patients Primary Cell Culture Proteins Pterygium - drug therapy Pterygium - genetics Pterygium - metabolism RNA Signal Transduction - drug effects Surgery Transcriptome Vascular endothelial growth factor
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