Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments per...
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| Veröffentlicht in: | PloS one 2012-06, Vol.7 (6), p.e39346 |
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| creator | Becker, Klaus Eder, Matthias Ranft, Andreas von Meyer, Ludwig Zieglgänsberger, Walter Kochs, Eberhard Dodt, Hans-Ulrich |
| description | The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity. |
| doi_str_mv | 10.1371/journal.pone.0039346 |
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However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0039346</identifier><identifier>PMID: 22723999</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anesthesia ; Anesthesiology ; Anesthetics ; Anesthetics, Inhalation - administration & dosage ; Anesthetics, Inhalation - pharmacology ; Animal experimentation ; Animals ; Biology ; Brain ; Brain research ; Brain slice preparation ; Dose-Response Relationship, Drug ; Electrodes ; Excitability ; Excitation ; Excitatory Postsynaptic Potentials - drug effects ; Experiments ; Halides ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Isoflurane ; Isoflurane - administration & dosage ; Isoflurane - pharmacology ; Light ; Male ; Medicine ; Microscopy ; Neocortex ; Neocortex - drug effects ; Neocortex - physiology ; Nerve Net - drug effects ; Nerve Net - physiology ; Neurons ; Optical communication ; Optical Imaging ; Physiological aspects ; Rats ; Rats, Sprague-Dawley ; Rodents</subject><ispartof>PloS one, 2012-06, Vol.7 (6), p.e39346</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Becker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Becker et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1c6f0239a3adef949ee0086faf30e522e2b0429e53e02bee420f88fecebf9c593</citedby><cites>FETCH-LOGICAL-c692t-1c6f0239a3adef949ee0086faf30e522e2b0429e53e02bee420f88fecebf9c593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377629/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377629/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22723999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Norris, Christopher Mark</contributor><creatorcontrib>Becker, Klaus</creatorcontrib><creatorcontrib>Eder, Matthias</creatorcontrib><creatorcontrib>Ranft, Andreas</creatorcontrib><creatorcontrib>von Meyer, Ludwig</creatorcontrib><creatorcontrib>Zieglgänsberger, Walter</creatorcontrib><creatorcontrib>Kochs, Eberhard</creatorcontrib><creatorcontrib>Dodt, Hans-Ulrich</creatorcontrib><title>Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.</description><subject>Anesthesia</subject><subject>Anesthesiology</subject><subject>Anesthetics</subject><subject>Anesthetics, Inhalation - administration & dosage</subject><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Animal experimentation</subject><subject>Animals</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain research</subject><subject>Brain slice preparation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrodes</subject><subject>Excitability</subject><subject>Excitation</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Experiments</subject><subject>Halides</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Isoflurane</subject><subject>Isoflurane - 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| subjects | Anesthesia Anesthesiology Anesthetics Anesthetics, Inhalation - administration & dosage Anesthetics, Inhalation - pharmacology Animal experimentation Animals Biology Brain Brain research Brain slice preparation Dose-Response Relationship, Drug Electrodes Excitability Excitation Excitatory Postsynaptic Potentials - drug effects Experiments Halides Hippocampus Hippocampus - drug effects Hippocampus - physiology Isoflurane Isoflurane - administration & dosage Isoflurane - pharmacology Light Male Medicine Microscopy Neocortex Neocortex - drug effects Neocortex - physiology Nerve Net - drug effects Nerve Net - physiology Neurons Optical communication Optical Imaging Physiological aspects Rats Rats, Sprague-Dawley Rodents |
| title | Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus |
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