Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice

Pregnane X receptor (PXR) is known to function as a xenobiotic sensor to regulate xenobiotic metabolism through selective transcription of genes responsible for maintaining physiological homeostasis. Here we report that the activation of PXR by pregnenolone 16α-carbonitrile (PCN) in AKR/J mice can p...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38734
Hauptverfasser:	Ma, Yongjie, Liu, Dexi
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Adipocytes - cytology Adipocytes - metabolism Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Adiposity - drug effects Animal tissues Animals ATP-binding protein Biology CD36 antigen Cytochrome Diabetes Diet Diet, High-Fat - adverse effects Energy Energy balance Energy metabolism Fatty acid-binding protein Fatty acids Gene expression Gene Expression Regulation - drug effects Genes Gluconeogenesis Glucose Glucose Tolerance Test Glucose-6-Phosphatase - genetics Growth rate High fat diet Homeostasis Inflammation Insulin Insulin - blood Insulin Resistance Ligands Lipid metabolism Lipid Metabolism - drug effects Lipid Metabolism - genetics Lipids Lipogenesis Liver Liver - drug effects Liver - metabolism Male Medicine Metabolism Metabolites Mice Mice, Inbred AKR Musculoskeletal system Obesity Obesity - etiology Obesity - metabolism Obesity - prevention & control Pathogenesis Pharmaceuticals Pharmacy Phosphatase Polymerase chain reaction Polypeptides Pregnenolone Pregnenolone Carbonitrile - administration & dosage Pregnenolone Carbonitrile - pharmacology Protein-Serine-Threonine Kinases - genetics Receptors, Steroid - agonists Receptors, Steroid - metabolism Rodents Sterol regulatory element-binding protein Thermogenesis Transcription activation
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