Isoflurane Induces Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier in a Transdifferentiated Human Umbilical Vein Edothelial Cell Model

Isoflurane is a popular volatile anesthetic agent used in humans as well as in experimental animal research. In previous animal studies of the blood-brain barrier (BBB), observations towards an increased permeability after exposure to isoflurane are reported. In this study we investigated the effect...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38260
Hauptverfasser:	Dittmar, Michael S, Petermichl, Walter, Schlachetzki, Felix, Graf, Bernhard M, Gruber, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesiology Apoptosis Bcl-2 protein Biology Blood-brain barrier Brain research Cell culture Cell growth Conditioning Deoxyribonucleic acid DNA DNA fragmentation Endothelial cells Endothelium Exposure Hypoxia Ischemia Isoflurane Light microscopy Lymphoma Medicine Membrane permeability Neuropathology NMR Nuclear magnetic resonance Permeability Rodents Traumatic brain injury Umbilical vein
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