Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha

Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatment processes, TCC has become a significant wa...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e37705
Hauptverfasser:	Yueh, Mei-Fei, Li, Tao, Evans, Ronald M, Hammock, Bruce, Tukey, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alcohol Animals Anti-Infective Agents, Local - pharmacology Antimicrobial agents Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Assaying Bioassays Biology Blotting, Western Cancer Carbanilides - pharmacology Cells, Cultured Chemistry Compartments Constitutive Androstane Receptor Cytochrome Cytochrome P-450 Cytochrome P-450 CYP1B1 Cytochrome P-450 CYP2B6 Environmental effects Environmental law Environmental monitoring Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogens Exposure Female Gene expression Gene Expression Regulation Genes Glucuronosyltransferase - physiology Health Health care Health care industry Homeostasis Humans Immunoenzyme Techniques Inactivation, Metabolic Laboratories Ligands Liver Luciferase Medicine Metabolism Metabolites Mice Microsomes, Liver - drug effects Microsomes, Liver - metabolism Ovaries Ovary - drug effects Ovary - metabolism Oxidoreductases, N-Demethylating - genetics Oxidoreductases, N-Demethylating - metabolism Personal care industry Personal care products Personal hygiene Phenobarbital Phenols (Class of compounds) Potamopyrgus antipodarum Promoter Regions, Genetic Real-Time Polymerase Chain Reaction Receptors Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Sensors Sewage Sewage treatment Studies Toxicology Transcription factors Triclocarban Waste treatment Wastewater treatment Wildlife Xenobiotics Xenobiotics - metabolism
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