Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible?

The antigenic similarity between tumors and embryos has been appreciated for many years and reflects the expression of embryonic gene products by cancer cells and/or cancer-initiating stem cells. Taking advantage of this similarity, we have tested a prophylactic lung cancer vaccine composed of allog...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e42289
Hauptverfasser:	Yaddanapudi, Kavitha, Mitchell, Robert A, Putty, Kalyani, Willer, Sharon, Sharma, Rajesh K, Yan, Jun, Bodduluri, Haribabu, Eaton, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen (tumor-associated) Antigens Biology Cancer Cancer genetics Cancer vaccines Cancer Vaccines - administration & dosage Carcinogens Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - prevention & control CD25 antigen CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Colony-stimulating factor Cytokines - biosynthesis Cytotoxicity Dendritic cells Embryo cells Embryo fibroblasts Embryonic Stem Cells Embryos Fibroblasts Foxp3 protein Gene expression Genetic aspects Granulocyte-macrophage colony-stimulating factor House mouse Immunity Immunologic Memory Immunological memory Immunostimulation Immunotherapy Leukocytes (granulocytic) Lung cancer Lung carcinoma Lung diseases Lymphocytes Lymphocytes T Macrophages Medical prognosis Medicine Melanoma Mice Ovarian cancer Similarity Spleen Stem cell transplantation Stem cells Studies Suppressor cells Surgical implants T cells Tumorigenesis Tumors Vaccination Vaccine efficacy Vaccines
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