Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen

Signal transduction pathways activated by Toll-like Receptors and the IL-1 family of cytokines are fundamental to mounting an innate immune response and thus to clearing pathogens and promoting wound healing. Whilst mechanistic understanding of the regulation of innate signalling pathways has advanc...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e42388-e42388
Hauptverfasser:	Wyllie, David H, Søgaard, Karen C, Holland, Karen, Yaobo, Xu, Bregu, Migena, Hill, Adrian V S, Kiss-Toth, Endre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Cell Line Cellular signal transduction Clearing Cloning Cytokines Deoxyribonucleic acid DNA Gene expression Genes Genetic screening Genetic testing Genome Genomes Genomics Identification Immune response Immune system Immunity Inflammation Inflammation - metabolism Inflammation - physiopathology Innate immunity Interleukin 1 Kinases Library collections Lipopolysaccharides Macrophages Macrophages - physiology Medicine Mice Potassium Proteins Receptors Regulators Rodents Signal processing Signal Transduction Signaling Toll-like receptors Variance analysis Wound healing
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