Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress
Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 de...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-07, Vol.7 (7), p.e42142-e42142 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e42142 |
|---|---|
| container_issue | 7 |
| container_start_page | e42142 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Hennebelle, Marie Balasse, Laure Latour, Alizée Champeil-Potokar, Gaelle Denis, Stéphanie Lavialle, Monique Gisquet-Verrier, Pascale Denis, Isabelle Vancassel, Sylvie |
| description | Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress. |
| doi_str_mv | 10.1371/journal.pone.0042142 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1325527297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A498243889</galeid><doaj_id>oai_doaj_org_article_bf9c55a6e12e4be2ac6a7ddf804e9846</doaj_id><sourcerecordid>A498243889</sourcerecordid><originalsourceid>FETCH-LOGICAL-c792t-5b914d80917bc2e68a3c42504fec1650117b6f930b09a9dd5d407d0af694141d3</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QDgrgXM-araXMjDIu6AwMLfuFdOE3SaZZOMzbp6vx7M053mS57IYU2nD7vm5y3PVn2kuA5YQV5f-2HvoN2vvWdnWPMKeH0UXZKJKMzQTF7fLQ-yZ6FcI1xzkohnmYnlJYCYyFOs5_Lrm4H22mLfI38xq5hxlANMe4QaGdQiBCHgHyHYmPRb9ihHmJAYGAbUfRIN73vnEa9DbEH18WkSOvwPHtSQxvsi_F5ln3_9PHbxeVsdfV5ebFYzXQhaZzllSTclFiSotLUihKY5jTHvLaaiByTVBe1ZLjCEqQxueG4MBhqITnhxLCz7PXBd9v6oMZQgiKM5jktqCwSsTwQxsO12vZuA_1OeXDqX8H3awV9dLq1qqqlznMQllDLK0tBCyiMqUvMrSy5SF4fxt2GamONtl1qup2YTt90rlFrf6MYxyXPaTI4Pxg092SXi5Xa1zAuSFEycUMS-27crPe_hpSv2rigbdtCZ_2QesSMkLxM94S-uYc-nMRIrSE167rapzPqvalacFlSzspSJmr-AJUuYzdOp7-tdqk-EZxPBImJ9k9cwxCCWn798v_s1Y8p-_aIbSy0sQm-HaLzXZiC_ADq3ofQ2_ouWYLVflhu01D7YVHjsCTZq-OPeSe6nQ72F4pZDSs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1325527297</pqid></control><display><type>article</type><title>Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Hennebelle, Marie ; Balasse, Laure ; Latour, Alizée ; Champeil-Potokar, Gaelle ; Denis, Stéphanie ; Lavialle, Monique ; Gisquet-Verrier, Pascale ; Denis, Isabelle ; Vancassel, Sylvie</creator><creatorcontrib>Hennebelle, Marie ; Balasse, Laure ; Latour, Alizée ; Champeil-Potokar, Gaelle ; Denis, Stéphanie ; Lavialle, Monique ; Gisquet-Verrier, Pascale ; Denis, Isabelle ; Vancassel, Sylvie</creatorcontrib><description>Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0042142</identifier><identifier>PMID: 22860066</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Agriculture ; Animal cognition ; Animals ; Anxiety ; Behavior, Animal ; Biology ; Body Weight ; Body weight loss ; Brain ; Brain research ; Chromatography, Gas ; Cognitive ability ; Corticosterone ; Corticosterone - blood ; Depression (Mood disorder) ; Diet ; Emotional behavior ; Emotional disorders ; Enrichment ; Fatty acids ; Fatty Acids, Omega-3 - metabolism ; Female ; Gas chromatography ; Glucocorticoid receptors ; Grooming ; Hippocampus - metabolism ; Immobilization ; Life Sciences ; Linolenic acid ; Linolenic acids ; Locomotor activity ; Medicine ; Mental depression ; Middle age ; Mood ; Neurons and Cognition ; Neurosciences ; Nutrient deficiency ; Nutrition research ; Omega 3 fatty acids ; Open-field behavior ; Rats ; Rats, Wistar ; Receptors ; Receptors, Glucocorticoid - metabolism ; Reducing diets ; Rodents ; Social and Behavioral Sciences ; Startle response ; Stress ; Stress (Psychology) ; Stress, Physiological ; Stresses ; Sucrose ; Sugar ; Veterinary Science ; Weight reduction</subject><ispartof>PloS one, 2012-07, Vol.7 (7), p.e42142-e42142</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Hennebelle et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2012 Hennebelle et al 2012 Hennebelle et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c792t-5b914d80917bc2e68a3c42504fec1650117b6f930b09a9dd5d407d0af694141d3</citedby><orcidid>0000-0003-4449-1377 ; 0000-0003-0208-5135 ; 0000-0003-0170-2963 ; 0000-0003-2086-7042</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408452/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408452/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22860066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00717836$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Hennebelle, Marie</creatorcontrib><creatorcontrib>Balasse, Laure</creatorcontrib><creatorcontrib>Latour, Alizée</creatorcontrib><creatorcontrib>Champeil-Potokar, Gaelle</creatorcontrib><creatorcontrib>Denis, Stéphanie</creatorcontrib><creatorcontrib>Lavialle, Monique</creatorcontrib><creatorcontrib>Gisquet-Verrier, Pascale</creatorcontrib><creatorcontrib>Denis, Isabelle</creatorcontrib><creatorcontrib>Vancassel, Sylvie</creatorcontrib><title>Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.</description><subject>Agriculture</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior, Animal</subject><subject>Biology</subject><subject>Body Weight</subject><subject>Body weight loss</subject><subject>Brain</subject><subject>Brain research</subject><subject>Chromatography, Gas</subject><subject>Cognitive ability</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Depression (Mood disorder)</subject><subject>Diet</subject><subject>Emotional behavior</subject><subject>Emotional disorders</subject><subject>Enrichment</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Female</subject><subject>Gas chromatography</subject><subject>Glucocorticoid receptors</subject><subject>Grooming</subject><subject>Hippocampus - metabolism</subject><subject>Immobilization</subject><subject>Life Sciences</subject><subject>Linolenic acid</subject><subject>Linolenic acids</subject><subject>Locomotor activity</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Middle age</subject><subject>Mood</subject><subject>Neurons and Cognition</subject><subject>Neurosciences</subject><subject>Nutrient deficiency</subject><subject>Nutrition research</subject><subject>Omega 3 fatty acids</subject><subject>Open-field behavior</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Reducing diets</subject><subject>Rodents</subject><subject>Social and Behavioral Sciences</subject><subject>Startle response</subject><subject>Stress</subject><subject>Stress (Psychology)</subject><subject>Stress, Physiological</subject><subject>Stresses</subject><subject>Sucrose</subject><subject>Sugar</subject><subject>Veterinary Science</subject><subject>Weight reduction</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QDgrgXM-araXMjDIu6AwMLfuFdOE3SaZZOMzbp6vx7M053mS57IYU2nD7vm5y3PVn2kuA5YQV5f-2HvoN2vvWdnWPMKeH0UXZKJKMzQTF7fLQ-yZ6FcI1xzkohnmYnlJYCYyFOs5_Lrm4H22mLfI38xq5hxlANMe4QaGdQiBCHgHyHYmPRb9ihHmJAYGAbUfRIN73vnEa9DbEH18WkSOvwPHtSQxvsi_F5ln3_9PHbxeVsdfV5ebFYzXQhaZzllSTclFiSotLUihKY5jTHvLaaiByTVBe1ZLjCEqQxueG4MBhqITnhxLCz7PXBd9v6oMZQgiKM5jktqCwSsTwQxsO12vZuA_1OeXDqX8H3awV9dLq1qqqlznMQllDLK0tBCyiMqUvMrSy5SF4fxt2GamONtl1qup2YTt90rlFrf6MYxyXPaTI4Pxg092SXi5Xa1zAuSFEycUMS-27crPe_hpSv2rigbdtCZ_2QesSMkLxM94S-uYc-nMRIrSE167rapzPqvalacFlSzspSJmr-AJUuYzdOp7-tdqk-EZxPBImJ9k9cwxCCWn798v_s1Y8p-_aIbSy0sQm-HaLzXZiC_ADq3ofQ2_ouWYLVflhu01D7YVHjsCTZq-OPeSe6nQ72F4pZDSs</recordid><startdate>20120730</startdate><enddate>20120730</enddate><creator>Hennebelle, Marie</creator><creator>Balasse, Laure</creator><creator>Latour, Alizée</creator><creator>Champeil-Potokar, Gaelle</creator><creator>Denis, Stéphanie</creator><creator>Lavialle, Monique</creator><creator>Gisquet-Verrier, Pascale</creator><creator>Denis, Isabelle</creator><creator>Vancassel, Sylvie</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4449-1377</orcidid><orcidid>https://orcid.org/0000-0003-0208-5135</orcidid><orcidid>https://orcid.org/0000-0003-0170-2963</orcidid><orcidid>https://orcid.org/0000-0003-2086-7042</orcidid></search><sort><creationdate>20120730</creationdate><title>Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress</title><author>Hennebelle, Marie ; Balasse, Laure ; Latour, Alizée ; Champeil-Potokar, Gaelle ; Denis, Stéphanie ; Lavialle, Monique ; Gisquet-Verrier, Pascale ; Denis, Isabelle ; Vancassel, Sylvie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c792t-5b914d80917bc2e68a3c42504fec1650117b6f930b09a9dd5d407d0af694141d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Agriculture</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Behavior, Animal</topic><topic>Biology</topic><topic>Body Weight</topic><topic>Body weight loss</topic><topic>Brain</topic><topic>Brain research</topic><topic>Chromatography, Gas</topic><topic>Cognitive ability</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Depression (Mood disorder)</topic><topic>Diet</topic><topic>Emotional behavior</topic><topic>Emotional disorders</topic><topic>Enrichment</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Female</topic><topic>Gas chromatography</topic><topic>Glucocorticoid receptors</topic><topic>Grooming</topic><topic>Hippocampus - metabolism</topic><topic>Immobilization</topic><topic>Life Sciences</topic><topic>Linolenic acid</topic><topic>Linolenic acids</topic><topic>Locomotor activity</topic><topic>Medicine</topic><topic>Mental depression</topic><topic>Middle age</topic><topic>Mood</topic><topic>Neurons and Cognition</topic><topic>Neurosciences</topic><topic>Nutrient deficiency</topic><topic>Nutrition research</topic><topic>Omega 3 fatty acids</topic><topic>Open-field behavior</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Reducing diets</topic><topic>Rodents</topic><topic>Social and Behavioral Sciences</topic><topic>Startle response</topic><topic>Stress</topic><topic>Stress (Psychology)</topic><topic>Stress, Physiological</topic><topic>Stresses</topic><topic>Sucrose</topic><topic>Sugar</topic><topic>Veterinary Science</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hennebelle, Marie</creatorcontrib><creatorcontrib>Balasse, Laure</creatorcontrib><creatorcontrib>Latour, Alizée</creatorcontrib><creatorcontrib>Champeil-Potokar, Gaelle</creatorcontrib><creatorcontrib>Denis, Stéphanie</creatorcontrib><creatorcontrib>Lavialle, Monique</creatorcontrib><creatorcontrib>Gisquet-Verrier, Pascale</creatorcontrib><creatorcontrib>Denis, Isabelle</creatorcontrib><creatorcontrib>Vancassel, Sylvie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hennebelle, Marie</au><au>Balasse, Laure</au><au>Latour, Alizée</au><au>Champeil-Potokar, Gaelle</au><au>Denis, Stéphanie</au><au>Lavialle, Monique</au><au>Gisquet-Verrier, Pascale</au><au>Denis, Isabelle</au><au>Vancassel, Sylvie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-07-30</date><risdate>2012</risdate><volume>7</volume><issue>7</issue><spage>e42142</spage><epage>e42142</epage><pages>e42142-e42142</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22860066</pmid><doi>10.1371/journal.pone.0042142</doi><tpages>e42142</tpages><orcidid>https://orcid.org/0000-0003-4449-1377</orcidid><orcidid>https://orcid.org/0000-0003-0208-5135</orcidid><orcidid>https://orcid.org/0000-0003-0170-2963</orcidid><orcidid>https://orcid.org/0000-0003-2086-7042</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-07, Vol.7 (7), p.e42142-e42142 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1325527297 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Agriculture Animal cognition Animals Anxiety Behavior, Animal Biology Body Weight Body weight loss Brain Brain research Chromatography, Gas Cognitive ability Corticosterone Corticosterone - blood Depression (Mood disorder) Diet Emotional behavior Emotional disorders Enrichment Fatty acids Fatty Acids, Omega-3 - metabolism Female Gas chromatography Glucocorticoid receptors Grooming Hippocampus - metabolism Immobilization Life Sciences Linolenic acid Linolenic acids Locomotor activity Medicine Mental depression Middle age Mood Neurons and Cognition Neurosciences Nutrient deficiency Nutrition research Omega 3 fatty acids Open-field behavior Rats Rats, Wistar Receptors Receptors, Glucocorticoid - metabolism Reducing diets Rodents Social and Behavioral Sciences Startle response Stress Stress (Psychology) Stress, Physiological Stresses Sucrose Sugar Veterinary Science Weight reduction |
| title | Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T23%3A49%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20omega-3%20fatty%20acid%20status%20on%20the%20way%20rats%20adapt%20to%20chronic%20restraint%20stress&rft.jtitle=PloS%20one&rft.au=Hennebelle,%20Marie&rft.date=2012-07-30&rft.volume=7&rft.issue=7&rft.spage=e42142&rft.epage=e42142&rft.pages=e42142-e42142&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0042142&rft_dat=%3Cgale_plos_%3EA498243889%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325527297&rft_id=info:pmid/22860066&rft_galeid=A498243889&rft_doaj_id=oai_doaj_org_article_bf9c55a6e12e4be2ac6a7ddf804e9846&rfr_iscdi=true |