Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice

The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J mice were fed a high-fat diet followed by low doses of streptozotocin to generate a type-2 diabetic model. OA (100 mg/kg/d...

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Veröffentlicht in:PloS one 2012-07, Vol.7 (7), p.e42115-e42115
Hauptverfasser: Zeng, Xiao-Yi, Wang, Yi-Ping, Cantley, James, Iseli, Tristan J, Molero, Juan Carlos, Hegarty, Bronwyn D, Kraegen, Edward W, Ye, Yang, Ye, Ji-Ming
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Sprache:eng
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