Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

In Huntington's disease (HD; MIM ID #143100), a fatal neurodegenerative disorder, transcriptional dysregulation is a key pathogenic feature. Histone modifications are altered in multiple cellular and animal models of HD suggesting a potential mechanism for the observed changes in transcriptiona...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41423
Hauptverfasser:	McFarland, Karen N, Das, Sudeshna, Sun, Ting Ting, Leyfer, Dmitri, Xia, Eva, Sangrey, Gavin R, Kuhn, Alexandre, Luthi-Carter, Ruth, Clark, Timothy W, Sadri-Vakili, Ghazaleh, Cha, Jang-Ho J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acetates Acetylation Acetylation - drug effects Amyotrophic lateral sclerosis Analysis Animal models Animals Binding sites Biology Brain Chromatin Coding Corpus Striatum - metabolism Corpus Striatum - pathology Correlation Deoxyribonucleic acid Disease Models, Animal DNA DNA methylation DNA microarrays Down-Regulation - drug effects Down-Regulation - genetics Enzymes Gene expression Gene loci Genes Genetic engineering Genetic Loci Genome Genome-Wide Association Study Genomes Genomics Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone H3 Histones - genetics Histones - metabolism Huntington Disease Huntington's disease Huntingtons disease Hybridization Immunoprecipitation Informatics Lysine Male Medicine Mice Mice, Transgenic Neostriatum Nervous system diseases Neural coding Neurodegeneration Neurodegenerative diseases Neurology Rodents Transcription Transcription (Genetics) Transgenic mice
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