Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone

Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropeptide that in mammals primarily regulates appetite and energy balance. We have recently identified a novel role for MCH in intestinal inflammation by demonstrating attenuated experimental colitis in MCH deficient mi...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41914
Hauptverfasser:	Nagel, Jutta M, Geiger, Brenda M, Karagiannis, Apostolos K A, Gras-Miralles, Beatriz, Horst, David, Najarian, Robert M, Ziogas, Dimitrios C, Chen, Xinhua, Kokkotou, Efi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - chemically induced Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenoma - chemically induced Adenoma - metabolism Adenoma - pathology Animals Antibodies Apoptosis Apoptosis - drug effects Appetite beta Catenin - metabolism Biology Caco-2 Cells Cancer Cancer research Cell proliferation Cell survival Cell Survival - drug effects Colitis Colon Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma Cytokines Dextran Dextran Sulfate - adverse effects Dextrans Disease Progression Energy balance Epithelial cells Evolutionary conservation Female Gastroenterology Gastrointestinal diseases Gene Expression Regulation, Neoplastic - drug effects Health aspects Health risks Hormones Humans Hypothalamic Hormones - deficiency Hypothalamus Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inhibition Insulin Insulin-like growth factors Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Neoplasms - chemically induced Intestinal Neoplasms - metabolism Intestinal Neoplasms - pathology Intestine Kinases Laboratory animals Male Medical schools Medical treatment Medicine Melanin Melanin-concentrating hormone Melanins - deficiency Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Mutation Pituitary Hormones - deficiency Receptors, Somatostatin - metabolism Risk reduction Rodents Signal transduction Signal Transduction - drug effects Signaling Small intestine Sodium Sodium sulfate Sodium sulfates Stem cells Stem Cells - drug effects Stem Cells - metabolism Survival Tumorigenesis Tumors Wnt protein Wnt Proteins - metabolism β-Catenin
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