Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) in ERCC4 may impact repair capacity and affect cancer s...
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| creator | Yu, Hongping Liu, Zhensheng Huang, Yu-Jing Yin, Ming Wang, Li-E Wei, Qingyi |
| description | Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) in ERCC4 may impact repair capacity and affect cancer susceptibility.
In this case-control study, we evaluated associations of four selected potentially functional SNPs in ERCC4 with risk of squamous cell carcinoma of the head and neck (SCCHN) in 1,040 non-Hispanic white patients with SCCHN and 1,046 cancer-free matched controls. We found that the variant GG genotype of rs2276466 was significantly associated with a decreased risk of SCCHN (OR = 0.69, 95% CI 0.50-0.96), and that the variant TT genotype of rs3136038 showed a borderline significant decreased risk with SCCHN (OR = 0.76, 95% CI: 0.58-1.01) in the recessive model. Such protective effects were more evident in oropharyngeal cancer (OR = 0.61, 95% CI: 0.40-0.92 for rs2276466; OR = 0.69, 95% CI: 0.48-0.98 for rs3136038). No significant associations were found for the other two SNPs (rs1800067 and rs1799798). In addition, individuals with the rs2276466 GG or with the rs3136038 TT genotypes had higher levels of ERCC4 mRNA expression than those with the corresponding wild-type genotypes in 90 Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Caucasians.
These results suggest that these two SNPs (rs2276466 and rs3136038) in ERCC4 may be functional and contribute to SCCHN susceptibility. However, our findings need to be replicated in further large epidemiological and functional studies. |
| doi_str_mv | 10.1371/journal.pone.0041853 |
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In this case-control study, we evaluated associations of four selected potentially functional SNPs in ERCC4 with risk of squamous cell carcinoma of the head and neck (SCCHN) in 1,040 non-Hispanic white patients with SCCHN and 1,046 cancer-free matched controls. We found that the variant GG genotype of rs2276466 was significantly associated with a decreased risk of SCCHN (OR = 0.69, 95% CI 0.50-0.96), and that the variant TT genotype of rs3136038 showed a borderline significant decreased risk with SCCHN (OR = 0.76, 95% CI: 0.58-1.01) in the recessive model. Such protective effects were more evident in oropharyngeal cancer (OR = 0.61, 95% CI: 0.40-0.92 for rs2276466; OR = 0.69, 95% CI: 0.48-0.98 for rs3136038). No significant associations were found for the other two SNPs (rs1800067 and rs1799798). In addition, individuals with the rs2276466 GG or with the rs3136038 TT genotypes had higher levels of ERCC4 mRNA expression than those with the corresponding wild-type genotypes in 90 Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Caucasians.
These results suggest that these two SNPs (rs2276466 and rs3136038) in ERCC4 may be functional and contribute to SCCHN susceptibility. However, our findings need to be replicated in further large epidemiological and functional studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0041853</identifier><identifier>PMID: 22848636</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alcohol use ; Binding sites ; Biology ; Biomarkers ; Cancer ; Cancer research ; Cancer therapies ; Carcinoma, Squamous Cell - genetics ; Chemotherapy ; Complementation ; Crosslinking ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; DNA damage ; DNA repair ; DNA-Binding Proteins - genetics ; Epidemiology ; Epstein-Barr virus ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic - genetics ; Genes ; Genetic aspects ; Genetic Predisposition to Disease - genetics ; Genomes ; Genotypes ; Head & neck cancer ; Head and Neck Neoplasms - genetics ; Hispanic Americans ; Humans ; Ionizing radiation ; Lymphoblastoid cell lines ; Male ; Medicine ; MicroRNAs ; Middle Aged ; Neck ; Nucleotide excision repair ; Oropharyngeal cancer ; Polymorphism, Single Nucleotide ; Proteins ; Repair ; Risk ; Risk factors ; RNA ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Squamous cell carcinoma ; Tumors ; Viruses ; Young Adult</subject><ispartof>PloS one, 2012-07, Vol.7 (7), p.e41853-e41853</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Yu et al 2012 Yu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-46886651c9a722da65485d42c750cd02595ffc54a161206d3771f5c9d6b3ae143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407112/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407112/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22848636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Hongping</creatorcontrib><creatorcontrib>Liu, Zhensheng</creatorcontrib><creatorcontrib>Huang, Yu-Jing</creatorcontrib><creatorcontrib>Yin, Ming</creatorcontrib><creatorcontrib>Wang, Li-E</creatorcontrib><creatorcontrib>Wei, Qingyi</creatorcontrib><title>Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) in ERCC4 may impact repair capacity and affect cancer susceptibility.
In this case-control study, we evaluated associations of four selected potentially functional SNPs in ERCC4 with risk of squamous cell carcinoma of the head and neck (SCCHN) in 1,040 non-Hispanic white patients with SCCHN and 1,046 cancer-free matched controls. We found that the variant GG genotype of rs2276466 was significantly associated with a decreased risk of SCCHN (OR = 0.69, 95% CI 0.50-0.96), and that the variant TT genotype of rs3136038 showed a borderline significant decreased risk with SCCHN (OR = 0.76, 95% CI: 0.58-1.01) in the recessive model. Such protective effects were more evident in oropharyngeal cancer (OR = 0.61, 95% CI: 0.40-0.92 for rs2276466; OR = 0.69, 95% CI: 0.48-0.98 for rs3136038). No significant associations were found for the other two SNPs (rs1800067 and rs1799798). In addition, individuals with the rs2276466 GG or with the rs3136038 TT genotypes had higher levels of ERCC4 mRNA expression than those with the corresponding wild-type genotypes in 90 Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Caucasians.
These results suggest that these two SNPs (rs2276466 and rs3136038) in ERCC4 may be functional and contribute to SCCHN susceptibility. However, our findings need to be replicated in further large epidemiological and functional studies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol use</subject><subject>Binding sites</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Chemotherapy</subject><subject>Complementation</subject><subject>Crosslinking</subject><subject>Deoxyribonucleic acid</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Epidemiology</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genomes</subject><subject>Genotypes</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Lymphoblastoid cell lines</subject><subject>Male</subject><subject>Medicine</subject><subject>MicroRNAs</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Nucleotide excision repair</subject><subject>Oropharyngeal cancer</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Repair</subject><subject>Risk</subject><subject>Risk factors</subject><subject>RNA</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAIHqxa76TuSksS9WFQqF-3IZsJrObdibZJjNq_72Z7rTsSC8kFwk5z3mTvDmnKF4jOEdEoE9XoY9eN_Nd8HYOIUWSkSfFMSoJnnEMydOD9VHxIqUrCBmRnD8vjjCWVHLCj4t-kVIwTncueLC23W9rPUjObxoLfG8aGzpXWbALzW0b4m7rUpuA8-DscrmkQPsKRJeuQahBuul1G_oEjG0aYHQ0zodWD6Fua8HW6uqO99Zcvyye1bpJ9tU4nxQ_Pp99X36dnV98WS0X5zMjmOxmlMt8X4ZMqQXGleaMSlZRnKPQVBCzktW1YVQjjjDkFREC1cyUFV8TbRElJ8Xbve6uCUmNjiWFCGYMI8wGYrUnqqCv1C66VsdbFbRTdxshbpSOnctGKFQJRLg0tLaCCm6lkZLWjCJD0NquddY6HU_r162tjPVd1M1EdBrxbqs24ZciFAqEcBb4MArEcNPb1KnWpcFO7W12ViFIIINYYJHRd_-gj79upDY6P8D5OuRzzSCqFrSUmNJSyEzNH6HyqGzrTC6v2uX9ScLHSUJmOvun2-g-JbX6dvn_7MXPKfv-gM0V03TbFJp-KM40BekeNDGkFG39YDKCauiOezfU0B1q7I6c9ubwgx6S7tuB_AVO-Alx</recordid><startdate>20120727</startdate><enddate>20120727</enddate><creator>Yu, Hongping</creator><creator>Liu, Zhensheng</creator><creator>Huang, Yu-Jing</creator><creator>Yin, Ming</creator><creator>Wang, Li-E</creator><creator>Wei, Qingyi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120727</creationdate><title>Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck</title><author>Yu, Hongping ; Liu, Zhensheng ; Huang, Yu-Jing ; Yin, Ming ; Wang, Li-E ; Wei, Qingyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-46886651c9a722da65485d42c750cd02595ffc54a161206d3771f5c9d6b3ae143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol use</topic><topic>Binding sites</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Chemotherapy</topic><topic>Complementation</topic><topic>Crosslinking</topic><topic>Deoxyribonucleic acid</topic><topic>Disease susceptibility</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA repair</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Epidemiology</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Lymphoblastoid cell lines</topic><topic>Male</topic><topic>Medicine</topic><topic>MicroRNAs</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Nucleotide excision repair</topic><topic>Oropharyngeal cancer</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins</topic><topic>Repair</topic><topic>Risk</topic><topic>Risk factors</topic><topic>RNA</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Hongping</creatorcontrib><creatorcontrib>Liu, Zhensheng</creatorcontrib><creatorcontrib>Huang, Yu-Jing</creatorcontrib><creatorcontrib>Yin, Ming</creatorcontrib><creatorcontrib>Wang, Li-E</creatorcontrib><creatorcontrib>Wei, Qingyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Hongping</au><au>Liu, Zhensheng</au><au>Huang, Yu-Jing</au><au>Yin, Ming</au><au>Wang, Li-E</au><au>Wei, Qingyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-07-27</date><risdate>2012</risdate><volume>7</volume><issue>7</issue><spage>e41853</spage><epage>e41853</epage><pages>e41853-e41853</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide polymorphisms (SNPs) in ERCC4 may impact repair capacity and affect cancer susceptibility.
In this case-control study, we evaluated associations of four selected potentially functional SNPs in ERCC4 with risk of squamous cell carcinoma of the head and neck (SCCHN) in 1,040 non-Hispanic white patients with SCCHN and 1,046 cancer-free matched controls. We found that the variant GG genotype of rs2276466 was significantly associated with a decreased risk of SCCHN (OR = 0.69, 95% CI 0.50-0.96), and that the variant TT genotype of rs3136038 showed a borderline significant decreased risk with SCCHN (OR = 0.76, 95% CI: 0.58-1.01) in the recessive model. Such protective effects were more evident in oropharyngeal cancer (OR = 0.61, 95% CI: 0.40-0.92 for rs2276466; OR = 0.69, 95% CI: 0.48-0.98 for rs3136038). No significant associations were found for the other two SNPs (rs1800067 and rs1799798). In addition, individuals with the rs2276466 GG or with the rs3136038 TT genotypes had higher levels of ERCC4 mRNA expression than those with the corresponding wild-type genotypes in 90 Epstein-Barr virus-transformed lymphoblastoid cell lines derived from Caucasians.
These results suggest that these two SNPs (rs2276466 and rs3136038) in ERCC4 may be functional and contribute to SCCHN susceptibility. However, our findings need to be replicated in further large epidemiological and functional studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22848636</pmid><doi>10.1371/journal.pone.0041853</doi><tpages>e41853</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Aged, 80 and over Alcohol use Binding sites Biology Biomarkers Cancer Cancer research Cancer therapies Carcinoma, Squamous Cell - genetics Chemotherapy Complementation Crosslinking Deoxyribonucleic acid Disease susceptibility DNA DNA damage DNA repair DNA-Binding Proteins - genetics Epidemiology Epstein-Barr virus Female Gene expression Gene Expression Regulation, Neoplastic - genetics Genes Genetic aspects Genetic Predisposition to Disease - genetics Genomes Genotypes Head & neck cancer Head and Neck Neoplasms - genetics Hispanic Americans Humans Ionizing radiation Lymphoblastoid cell lines Male Medicine MicroRNAs Middle Aged Neck Nucleotide excision repair Oropharyngeal cancer Polymorphism, Single Nucleotide Proteins Repair Risk Risk factors RNA Single nucleotide polymorphisms Single-nucleotide polymorphism Squamous cell carcinoma Tumors Viruses Young Adult |
| title | Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T13%3A31%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20single%20nucleotide%20polymorphisms%20in%20ERCC4%20and%20risk%20of%20squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck&rft.jtitle=PloS%20one&rft.au=Yu,%20Hongping&rft.date=2012-07-27&rft.volume=7&rft.issue=7&rft.spage=e41853&rft.epage=e41853&rft.pages=e41853-e41853&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0041853&rft_dat=%3Cgale_plos_%3EA498244978%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325521254&rft_id=info:pmid/22848636&rft_galeid=A498244978&rft_doaj_id=oai_doaj_org_article_1d71368c4fe7476e8c884f541c31beba&rfr_iscdi=true |