A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C

To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the respo...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40159
Hauptverfasser:	Lange, Christian M, Bibert, Stephanie, Kutalik, Zoltan, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean-Francois, Geier, Andreas, Gerlach, Tilman J, Heim, Markus H, Malinverni, Raffaele, Negro, Francesco, Regenass, Stephan, Badenhoop, Klaus, Bojunga, Jörg, Sarrazin, Christoph, Zeuzem, Stefan, Müller, Tobias, Berg, Thomas, Bochud, Pierre-Yves, Moradpour, Darius
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Adult Aged Antigens Biological products industry Biological response modifiers Biology Calcifediol - blood Calcitriol Clinical outcomes Cytochrome P-450 Demography Diabetes Female Gastroenterology Gene Frequency - genetics Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genomes Genotype & phenotype Genotypes Hepatitis Hepatitis C Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - virology Hepatology Hospitals Humans Hydroxylase Infectious diseases Interferon Interferon-alpha - therapeutic use Interferons Interleukins - genetics Male Medicine Metabolism Middle Aged Multiple sclerosis Patients Physiological aspects Polyethylene glycol Polymorphism Polymorphism, Single Nucleotide - genetics Reproducibility of Results Ribavirin Ribavirin - therapeutic use Seasons Serum levels Therapy Treatment Outcome Vitamin D Vitamin D - blood Vitamin D - metabolism Vitamin deficiency Young Adult α-Interferon
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