Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein

The IGROVCDDP cisplatin-resistant ovarian cancer cell line is also resistant to paclitaxel and models the resistance phenotype of relapsed ovarian cancer patients after first-line platinum/taxane chemotherapy. A TaqMan low-density array (TLDA) was used to characterise the expression of 380 genes ass...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40717
Hauptverfasser:	Stordal, Britta, Hamon, Marion, McEneaney, Victoria, Roche, Sandra, Gillet, Jean-Pierre, O'Leary, John J, Gottesman, Michael, Clynes, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenosine triphosphatase Analysis Antineoplastic Agents - pharmacology Apoptosis ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism Biology Biomarkers - metabolism Biotechnology BRCA1 protein Breast cancer Cancer Cancer therapies Cation Transport Proteins - metabolism Cell Line, Tumor Cellular stress response Chemistry Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Copper Copper Transporter 1 Cytotoxicity Drug resistance Drug Resistance, Neoplasm - genetics Enzymatic activity Enzyme activity Enzymes Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genes, BRCA1 Genetic aspects Glutathione Glutathione - metabolism Glycoproteins Hematology Histopathology Humans Laboratories Medical prognosis Medical research Medicine Metabolic Networks and Pathways Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism P-Glycoprotein Paclitaxel Paclitaxel - pharmacology Patients Phenotypes Platinum Position (location) Potassium Protein expression Proteins Sodium Substrates Systematic review Taxane Taxanes Transporter
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