Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach

Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. Numerous fucosylated antigens in sera serve as tumor markers for cancer detection and evaluation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e39545
Hauptverfasser:	Yoshida, Makoto, Takimoto, Rishu, Murase, Kazuyuki, Sato, Yasushi, Hirakawa, Masahiro, Tamura, Fumito, Sato, Tsutomu, Iyama, Satoshi, Osuga, Takahiro, Miyanishi, Koji, Takada, Kohichi, Hayashi, Tsuyoshi, Kobune, Masayoshi, Kato, Junji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - therapy Analysis Animal models Animals Antigens Antineoplastic Agents - administration & dosage Antineoplastic drugs Antitumor agents Biochemistry Biology Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer cells Cancer therapies Carbocyanines Cell Line, Tumor Cell survival Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chemotherapy Cisplatin Cisplatin - administration & dosage Diagnosis Drug delivery Drug Delivery Systems Drug therapy E coli Enzymes Escherichia coli Female Fucose Fucose - metabolism Fucosyltransferases - genetics Fucosyltransferases - metabolism Gene Expression Regulation, Neoplastic Growth inhibition Homeostasis Humans Internal medicine L-fucose Laboratories Lectins Ligands Liposomes Liposomes - chemistry Liver cancer Medical prognosis Medicine Mice Mice, Nude Nanoparticles Nanoparticles - chemistry Oncology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - therapy Physicians Polyethylene glycol Prognosis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Survival Survival Rate Transformation Tumor markers University graduates Xenograft Model Antitumor Assays Xenografts Xenotransplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!