A foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomers

Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity through their helical folda...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e39485
Hauptverfasser:	Fülöp, Lívia, Mándity, István M, Juhász, Gábor, Szegedi, Viktor, Hetényi, Anasztázia, Wéber, Edit, Bozsó, Zsolt, Simon, Dóra, Benkő, Mária, Király, Zoltán, Martinek, Tamás A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Alzheimers disease Amino acids Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - physiology Animals Binding Binding sites Biochemical tests Biochemistry Biology Biomimetic materials Calorimetry Chemical Precipitation Chemistry Chromatography Conjugates Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology Design Electron microscopy Enzyme-linked immunosorbent assay Helices Hippocampus Hippocampus - drug effects Hippocampus - physiopathology Immunoglobulins In Vitro Techniques Inhibition Ligands Light Light scattering Long-term potentiation Long-Term Potentiation - drug effects Low molecular weights Magnetic Resonance Spectroscopy Materials science Medicine Mice Molecular Mimicry Molecular weight Neurodegenerative diseases Neurosciences NMR Nuclear magnetic resonance Oligomers Overhauser effect Particle Size Pattern recognition Peptides Pharmaceuticals Photon correlation spectroscopy Physical chemistry Polymers Potentiation Protein Binding Protein Structure, Secondary Proteins Scattering, Radiation Tentacles Titration Titration calorimetry Transmission electron microscopy β-Amyloid
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