Noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53

Neuroblastoma is the most common extracranial solid tumor of childhood. It accounts for 15% of pediatric cancer deaths. Chemotherapy is the mainstay of treatment in children with advanced neuroblastoma. Noscapine, a nontoxic natural compound, can trigger apoptosis in many cancer types. We now show t...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40076
Hauptverfasser:	Li, Shiwang, He, Jing, Li, Shuai, Cao, Guoqing, Tang, Shaotao, Tong, Qiangsong, Joshi, Harish C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitussive Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Biochemistry Biology Biotechnology Breast cancer Cancer Cancer prevention Cancer therapies Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase-3 Cell cycle Cell death Cell division Cell growth Cell Line, Tumor Chemistry Chemotherapy Children Circuits Cytotoxicity Deoxyribonucleic acid DNA DNA fragmentation DNA Fragmentation - drug effects Down-Regulation - drug effects Down-Regulation - genetics Ectopic expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Inhibitor of Apoptosis Proteins - biosynthesis Inhibitor of Apoptosis Proteins - genetics Medicine Morphology mRNA Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma cells Noscapine - pharmacology p53 Protein Pediatrics Phosphorylation - drug effects Phosphorylation - genetics Polymerization Proteins Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism RNA-mediated interference Science Solid tumors Statistical analysis Surgery Survivin Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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