High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation

Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP) MIN6 cells lose their ability to secrete insulin in respons...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40868
Hauptverfasser:	Cheng, Kim, Delghingaro-Augusto, Viviane, Nolan, Christopher J, Turner, Nigel, Hallahan, Nicole, Andrikopoulos, Sofianos, Gunton, Jenny E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals ATP Beta cells Biology Cell Culture Techniques - methods Cell growth Cell Line, Tumor Cell Proliferation Cell Shape Chromosomes Colorectal cancer Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Enzymes Gene expression Gene Expression Regulation Glucose Glucose - metabolism Homeostasis Insulin Insulin - metabolism Insulin resistance Insulin Secretion Intracellular Space - metabolism Lactic Acid - metabolism Lipid Metabolism Lipid peroxidation Lipids Medical research Medicine Metabolic disorders Metabolism Mice Microscopy Mitochondrial uncoupling protein 2 Models, Biological Oxidation Oxidation-Reduction Oxidation-reduction reactions Physiological aspects Proteins Rodents Secretion Transcription factors Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!