Rapid changes in cardiac myofilament function following the acute activation of estrogen receptor-alpha

Estrogens have well-recognized and complex cardiovascular effects, including altering myocardial contractility through changes in myofilament function. The presence of multiple estrogen receptor (ER) isoforms in the heart may explain some discrepant findings about the cardiac effects of estrogens. M...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41076-e41076
Hauptverfasser:	Kulpa, Justyna, Chinnappareddy, Nirmala, Pyle, W Glen
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Actomyosin Animals Biology Calcium Calcium-binding protein Estrogen Receptor alpha - metabolism Estrogen Receptor alpha - physiology Estrogen receptors Estrogens Estrogens - pharmacology Female Heart Heart diseases Heart function Heart Ventricles - cytology Hormone replacement therapy Imidazoles - pharmacology In Vitro Techniques Isoforms Kinases MAP kinase Medicine Mice Mice, Inbred C57BL Muscle contraction Muscle Proteins - metabolism Myofibrils - drug effects Myofibrils - metabolism Myofibrils - physiology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phenols (Class of compounds) Phenols - pharmacology Phosphorylation Protein kinase A Protein Processing, Post-Translational Pyrazoles - pharmacology Pyridines - pharmacology Rodents Signal transduction Signaling Stimulation Troponin Troponin I Troponin I - metabolism Ventricular Function, Left - drug effects Ventricular Pressure - drug effects
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