Angiotensin II contributes to renal fibrosis independently of Notch pathway activation

Recent studies have described that the Notch signaling pathway is activated in a wide range of renal diseases. Angiotensin II (AngII) plays a key role in the progression of kidney diseases. AngII contributes to renal fibrosis by upregulation of profibrotic factors, induction of epithelial mesenchyma...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40490
Hauptverfasser:	Lavoz, Carolina, Rodrigues-Diez, Raquel, Benito-Martin, Alberto, Rayego-Mateos, Sandra, Rodrigues-Diez, Raúl R, Alique, Matilde, Ortiz, Alberto, Mezzano, Sergio, Egido, Jesús, Ruiz-Ortega, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Angiotensin Angiotensin II Angiotensin II - administration & dosage Angiotensin II - toxicity Angiotensins Animals Apoptosis Biology Bone morphogenetic proteins Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Line Cellular biology Development and progression Diabetes Disease Models, Animal Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Extracellular matrix Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Gene expression Gene Expression Regulation - drug effects Genes Human behavior Humans Hydronephrosis - genetics Hydronephrosis - metabolism Hypertension Hypertension - chemically induced Hypertension - genetics Hypertension - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Jagged-1 Protein Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney diseases Kidney Tubules - drug effects Kidney Tubules - metabolism Kidneys Laboratories Ligands Male Medicine Membrane Proteins - genetics Membrane Proteins - metabolism Mesenchyme Mice Mice, Inbred C57BL Nephrology Notch protein Notch1 protein Nuclear transport Pharmacology Podocytes - drug effects Podocytes - metabolism Proteins Rats Receptor, Angiotensin, Type 1 - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism Regeneration Rodents Serrate-Jagged Proteins Signal Transduction Signaling Smooth muscle Stem cells Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Transforming growth factors Translocation Vascular endothelial growth factor
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