Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy
The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infection. HAM/TSP can present with an acute/subacute form of longitu...
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| Veröffentlicht in: | PloS one 2012-07, Vol.7 (7), p.e39372-e39372 |
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| creator | von Glehn, Felipe Jarius, Sven Penalva de Oliveira, Augusto C Brandão, Carlos Otávio Farias, Alessandro S Damasceno, Alfredo Casseb, Jorge Moraes, Adriel S Longhini, Ana Leda F Wandinger, Klaus-Peter Damasceno, Benito P Wildemann, Brigitte Santos, Leonilda M B |
| description | The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infection. HAM/TSP can present with an acute/subacute form of longitudinally extensive myelitis, which can be confused with lesions seen in aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorders (NMOSD) on MRI. Moreover, clinical attacks in patients with NMOSD have been shown to be preceded by viral infections in around 30% of cases.
To evaluate the frequency of AQP4-Ab in patients with HAM/TSP. To evaluate the frequency of HTLV-1 infection in patients with NMOSD.
23 Brazilian patients with HAM/TSP, 20 asymptomatic HTLV-1+ serostatus patients, and 34 with NMOSD were tested for AQP4-Ab using a standardized recombinant cell based assay. In addition, all patients were tested for HTLV-1 by ELISA and Western blotting.
20/34 NMOSD patients were positive for AQP4-Ab but none of the HAM/TSP patients and none of the asymptomatic HTLV-1 infected individuals. Conversely, all AQP4-Ab-positive NMOSD patients were negative for HTLV-1 antibodies. One patient with HAM/TSP developed optic neuritis in addition to subacute LETM; this patient was AQP4-Ab negative as well. Patients were found to be predominantly female and of African descent both in the NMOSD and in the HAM/TSP group; Osame scale and expanded disability status scale scores did not differ significantly between the two groups.
Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence. |
| doi_str_mv | 10.1371/journal.pone.0039372 |
| format | Article |
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To evaluate the frequency of AQP4-Ab in patients with HAM/TSP. To evaluate the frequency of HTLV-1 infection in patients with NMOSD.
23 Brazilian patients with HAM/TSP, 20 asymptomatic HTLV-1+ serostatus patients, and 34 with NMOSD were tested for AQP4-Ab using a standardized recombinant cell based assay. In addition, all patients were tested for HTLV-1 by ELISA and Western blotting.
20/34 NMOSD patients were positive for AQP4-Ab but none of the HAM/TSP patients and none of the asymptomatic HTLV-1 infected individuals. Conversely, all AQP4-Ab-positive NMOSD patients were negative for HTLV-1 antibodies. One patient with HAM/TSP developed optic neuritis in addition to subacute LETM; this patient was AQP4-Ab negative as well. Patients were found to be predominantly female and of African descent both in the NMOSD and in the HAM/TSP group; Osame scale and expanded disability status scale scores did not differ significantly between the two groups.
Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0039372</identifier><identifier>PMID: 22808032</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; African Americans ; Aged ; Aged, 80 and over ; Antibodies ; Antigens ; Aquaporin 4 ; Aquaporin 4 - blood ; Aquaporin 4 - immunology ; Aquaporins ; Autoantibodies - blood ; Autoantibodies - immunology ; Bacterial infections ; Biology ; Blotting, Western ; Brazil - epidemiology ; Cell growth ; Central nervous system diseases ; Cytokines ; Development and progression ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Female ; Health aspects ; Hepatitis ; HIV ; Human immunodeficiency virus ; Human T-lymphotropic virus 1 - physiology ; Humans ; Immunoglobulins ; Infection ; Infections ; Infectious diseases ; Lesions ; Leukemia ; Lymphocytes T ; Magnetic Resonance Imaging ; Male ; Medicine ; Middle Aged ; Multiple sclerosis ; Myelitis ; Neuritis ; Neurology ; Neuromyelitis ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - diagnosis ; Neuromyelitis Optica - ethnology ; Neuromyelitis Optica - immunology ; NMR ; Nuclear magnetic resonance ; Optic neuritis ; Paraparesis, Tropical Spastic - blood ; Paraparesis, Tropical Spastic - diagnosis ; Paraparesis, Tropical Spastic - ethnology ; Paraparesis, Tropical Spastic - immunology ; Pathogenesis ; Patients ; Quality of life ; RNA, Viral - blood ; Serology ; Sex Factors ; Spastic paraparesis ; Spinal cord ; T cells ; Tropical spastic paraparesis ; Virus diseases ; Viruses ; Western blotting ; Young Adult</subject><ispartof>PloS one, 2012-07, Vol.7 (7), p.e39372-e39372</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 von Glehn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>von Glehn et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-44a70e1aa2782710217577a81cf43e18492888c274d69e6ddcceb4017eb6715e3</citedby><cites>FETCH-LOGICAL-c692t-44a70e1aa2782710217577a81cf43e18492888c274d69e6ddcceb4017eb6715e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393709/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393709/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22808032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kleinschnitz, Christoph</contributor><creatorcontrib>von Glehn, Felipe</creatorcontrib><creatorcontrib>Jarius, Sven</creatorcontrib><creatorcontrib>Penalva de Oliveira, Augusto C</creatorcontrib><creatorcontrib>Brandão, Carlos Otávio</creatorcontrib><creatorcontrib>Farias, Alessandro S</creatorcontrib><creatorcontrib>Damasceno, Alfredo</creatorcontrib><creatorcontrib>Casseb, Jorge</creatorcontrib><creatorcontrib>Moraes, Adriel S</creatorcontrib><creatorcontrib>Longhini, Ana Leda F</creatorcontrib><creatorcontrib>Wandinger, Klaus-Peter</creatorcontrib><creatorcontrib>Damasceno, Benito P</creatorcontrib><creatorcontrib>Wildemann, Brigitte</creatorcontrib><creatorcontrib>Santos, Leonilda M B</creatorcontrib><title>Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infection. HAM/TSP can present with an acute/subacute form of longitudinally extensive myelitis, which can be confused with lesions seen in aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorders (NMOSD) on MRI. Moreover, clinical attacks in patients with NMOSD have been shown to be preceded by viral infections in around 30% of cases.
To evaluate the frequency of AQP4-Ab in patients with HAM/TSP. To evaluate the frequency of HTLV-1 infection in patients with NMOSD.
23 Brazilian patients with HAM/TSP, 20 asymptomatic HTLV-1+ serostatus patients, and 34 with NMOSD were tested for AQP4-Ab using a standardized recombinant cell based assay. In addition, all patients were tested for HTLV-1 by ELISA and Western blotting.
20/34 NMOSD patients were positive for AQP4-Ab but none of the HAM/TSP patients and none of the asymptomatic HTLV-1 infected individuals. Conversely, all AQP4-Ab-positive NMOSD patients were negative for HTLV-1 antibodies. One patient with HAM/TSP developed optic neuritis in addition to subacute LETM; this patient was AQP4-Ab negative as well. Patients were found to be predominantly female and of African descent both in the NMOSD and in the HAM/TSP group; Osame scale and expanded disability status scale scores did not differ significantly between the two groups.
Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Aquaporin 4</subject><subject>Aquaporin 4 - blood</subject><subject>Aquaporin 4 - immunology</subject><subject>Aquaporins</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Bacterial infections</subject><subject>Biology</subject><subject>Blotting, Western</subject><subject>Brazil - epidemiology</subject><subject>Cell growth</subject><subject>Central nervous system diseases</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Diagnosis, Differential</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Human T-lymphotropic virus 1 - physiology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infection</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Leukemia</subject><subject>Lymphocytes T</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Myelitis</subject><subject>Neuritis</subject><subject>Neurology</subject><subject>Neuromyelitis</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>Neuromyelitis Optica - ethnology</subject><subject>Neuromyelitis Optica - immunology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Optic neuritis</subject><subject>Paraparesis, Tropical Spastic - blood</subject><subject>Paraparesis, Tropical Spastic - diagnosis</subject><subject>Paraparesis, Tropical Spastic - ethnology</subject><subject>Paraparesis, Tropical Spastic - immunology</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Quality of life</subject><subject>RNA, Viral - blood</subject><subject>Serology</subject><subject>Sex Factors</subject><subject>Spastic paraparesis</subject><subject>Spinal cord</subject><subject>T cells</subject><subject>Tropical spastic paraparesis</subject><subject>Virus diseases</subject><subject>Viruses</subject><subject>Western blotting</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYqPwDxBEQkJwkeKvxM4NUjUxVqnSJBi7tVznpHWVxJ3tIPrvcdZsatAukC9sHT_nPcfHb5K8xWiOKcdfdrZ3nWrme9vBHCFaUk6eJee4pCQrCKLPT85nySvvdwjlVBTFy-SMEIEEouQ8uVzc9WpvnekylqoumLWtDPhUOUg7G1IHjQpQpcGmVzer2wynynurzX2wPUBj9ypsD6-TF7VqPLwZ91ny6_LbzcVVtrr-vrxYrDJdlCRkjCmOACtFuCAcI4J5zrkSWNeMAhasJEIITTirihKKqtIa1gxhDuuC4xzoLHl_1N031stxBF5iSnJaFgjTSCyPRGXVTu6daZU7SKuMvA9Yt5HKBaMbkEByRHkpasIRYzqeSgKMqxzlJYdcRK2vY7V-3UKloQtONRPR6U1ntnJjf0s6_AYqo8CnUcDZux58kK3xGppGdWD72DcaShOKhr4__IM-_bqR2qj4ANPVNtbVg6hcMM4xpnnEZsn8CSquClqjo19qE-OThM-ThMgE-BM2qvdeLn_--H_2-nbKfjxht6CasPW26YOxnZ-C7AhqZ713UD8OGSM52P1hGnKwuxztHtPenX7QY9KDv-lfziH2TQ</recordid><startdate>20120710</startdate><enddate>20120710</enddate><creator>von Glehn, Felipe</creator><creator>Jarius, Sven</creator><creator>Penalva de Oliveira, Augusto C</creator><creator>Brandão, Carlos Otávio</creator><creator>Farias, Alessandro S</creator><creator>Damasceno, Alfredo</creator><creator>Casseb, Jorge</creator><creator>Moraes, Adriel S</creator><creator>Longhini, Ana Leda F</creator><creator>Wandinger, Klaus-Peter</creator><creator>Damasceno, Benito P</creator><creator>Wildemann, Brigitte</creator><creator>Santos, Leonilda M B</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120710</creationdate><title>Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy</title><author>von Glehn, Felipe ; Jarius, Sven ; Penalva de Oliveira, Augusto C ; Brandão, Carlos Otávio ; Farias, Alessandro S ; Damasceno, Alfredo ; Casseb, Jorge ; Moraes, Adriel S ; Longhini, Ana Leda F ; Wandinger, Klaus-Peter ; Damasceno, Benito P ; Wildemann, Brigitte ; Santos, Leonilda M B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-44a70e1aa2782710217577a81cf43e18492888c274d69e6ddcceb4017eb6715e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Aquaporin 4</topic><topic>Aquaporin 4 - blood</topic><topic>Aquaporin 4 - immunology</topic><topic>Aquaporins</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Bacterial infections</topic><topic>Biology</topic><topic>Blotting, Western</topic><topic>Brazil - epidemiology</topic><topic>Cell growth</topic><topic>Central nervous system diseases</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Diagnosis, Differential</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Human T-lymphotropic virus 1 - physiology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infection</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Leukemia</topic><topic>Lymphocytes T</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Myelitis</topic><topic>Neuritis</topic><topic>Neurology</topic><topic>Neuromyelitis</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - diagnosis</topic><topic>Neuromyelitis Optica - ethnology</topic><topic>Neuromyelitis Optica - immunology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Optic neuritis</topic><topic>Paraparesis, Tropical Spastic - blood</topic><topic>Paraparesis, Tropical Spastic - diagnosis</topic><topic>Paraparesis, Tropical Spastic - ethnology</topic><topic>Paraparesis, Tropical Spastic - immunology</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Quality of life</topic><topic>RNA, Viral - blood</topic><topic>Serology</topic><topic>Sex Factors</topic><topic>Spastic paraparesis</topic><topic>Spinal cord</topic><topic>T cells</topic><topic>Tropical spastic paraparesis</topic><topic>Virus diseases</topic><topic>Viruses</topic><topic>Western blotting</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Glehn, Felipe</creatorcontrib><creatorcontrib>Jarius, Sven</creatorcontrib><creatorcontrib>Penalva de Oliveira, Augusto C</creatorcontrib><creatorcontrib>Brandão, Carlos Otávio</creatorcontrib><creatorcontrib>Farias, Alessandro S</creatorcontrib><creatorcontrib>Damasceno, Alfredo</creatorcontrib><creatorcontrib>Casseb, Jorge</creatorcontrib><creatorcontrib>Moraes, Adriel S</creatorcontrib><creatorcontrib>Longhini, Ana Leda F</creatorcontrib><creatorcontrib>Wandinger, Klaus-Peter</creatorcontrib><creatorcontrib>Damasceno, Benito P</creatorcontrib><creatorcontrib>Wildemann, Brigitte</creatorcontrib><creatorcontrib>Santos, Leonilda M B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Glehn, Felipe</au><au>Jarius, Sven</au><au>Penalva de Oliveira, Augusto C</au><au>Brandão, Carlos Otávio</au><au>Farias, Alessandro S</au><au>Damasceno, Alfredo</au><au>Casseb, Jorge</au><au>Moraes, Adriel S</au><au>Longhini, Ana Leda F</au><au>Wandinger, Klaus-Peter</au><au>Damasceno, Benito P</au><au>Wildemann, Brigitte</au><au>Santos, Leonilda M B</au><au>Kleinschnitz, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-07-10</date><risdate>2012</risdate><volume>7</volume><issue>7</issue><spage>e39372</spage><epage>e39372</epage><pages>e39372-e39372</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infection. HAM/TSP can present with an acute/subacute form of longitudinally extensive myelitis, which can be confused with lesions seen in aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorders (NMOSD) on MRI. Moreover, clinical attacks in patients with NMOSD have been shown to be preceded by viral infections in around 30% of cases.
To evaluate the frequency of AQP4-Ab in patients with HAM/TSP. To evaluate the frequency of HTLV-1 infection in patients with NMOSD.
23 Brazilian patients with HAM/TSP, 20 asymptomatic HTLV-1+ serostatus patients, and 34 with NMOSD were tested for AQP4-Ab using a standardized recombinant cell based assay. In addition, all patients were tested for HTLV-1 by ELISA and Western blotting.
20/34 NMOSD patients were positive for AQP4-Ab but none of the HAM/TSP patients and none of the asymptomatic HTLV-1 infected individuals. Conversely, all AQP4-Ab-positive NMOSD patients were negative for HTLV-1 antibodies. One patient with HAM/TSP developed optic neuritis in addition to subacute LETM; this patient was AQP4-Ab negative as well. Patients were found to be predominantly female and of African descent both in the NMOSD and in the HAM/TSP group; Osame scale and expanded disability status scale scores did not differ significantly between the two groups.
Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22808032</pmid><doi>10.1371/journal.pone.0039372</doi><tpages>e39372</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-07, Vol.7 (7), p.e39372-e39372 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1325396013 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult African Americans Aged Aged, 80 and over Antibodies Antigens Aquaporin 4 Aquaporin 4 - blood Aquaporin 4 - immunology Aquaporins Autoantibodies - blood Autoantibodies - immunology Bacterial infections Biology Blotting, Western Brazil - epidemiology Cell growth Central nervous system diseases Cytokines Development and progression Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Female Health aspects Hepatitis HIV Human immunodeficiency virus Human T-lymphotropic virus 1 - physiology Humans Immunoglobulins Infection Infections Infectious diseases Lesions Leukemia Lymphocytes T Magnetic Resonance Imaging Male Medicine Middle Aged Multiple sclerosis Myelitis Neuritis Neurology Neuromyelitis Neuromyelitis Optica - blood Neuromyelitis Optica - diagnosis Neuromyelitis Optica - ethnology Neuromyelitis Optica - immunology NMR Nuclear magnetic resonance Optic neuritis Paraparesis, Tropical Spastic - blood Paraparesis, Tropical Spastic - diagnosis Paraparesis, Tropical Spastic - ethnology Paraparesis, Tropical Spastic - immunology Pathogenesis Patients Quality of life RNA, Viral - blood Serology Sex Factors Spastic paraparesis Spinal cord T cells Tropical spastic paraparesis Virus diseases Viruses Western blotting Young Adult |
| title | Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T02%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aquaporin-4%20antibodies%20are%20not%20related%20to%20HTLV-1%20associated%20myelopathy&rft.jtitle=PloS%20one&rft.au=von%20Glehn,%20Felipe&rft.date=2012-07-10&rft.volume=7&rft.issue=7&rft.spage=e39372&rft.epage=e39372&rft.pages=e39372-e39372&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0039372&rft_dat=%3Cgale_plos_%3EA477113501%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325396013&rft_id=info:pmid/22808032&rft_galeid=A477113501&rft_doaj_id=oai_doaj_org_article_e2503798f27044c79892e47a50597e58&rfr_iscdi=true |