Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE

There is a strong need for a recombinant subunit vaccine against fowl cholera. We used a reverse vaccinology approach to identify putative secreted or cell surface associated P. multocida proteins that may represent potential vaccine candidate antigens. A high-throughput cloning and expression proto...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e39973-e39973
Hauptverfasser:	Hatfaludi, Tamás, Al-Hasani, Keith, Gong, Lan, Boyce, John D, Ford, Mark, Wilkie, Ian W, Quinsey, Noelene, Dunstone, Michelle A, Hoke, David E, Adler, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antigens, Bacterial - isolation & purification Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - isolation & purification Bacterial Vaccines - immunology Biochemistry Bioinformatics Biology Cell surface Chickens Chickens - immunology Chickens - microbiology Cholera Cloning Councils Disease Models, Animal E coli Ehrlichia chaffeensis Female Fowl cholera Gene Expression Genomes Genomics Identification Immune response Immune system Immunity Immunofluorescence Infections Laboratories Medical screening Medicine Mice Molecular biology Mutant Proteins - genetics Mutant Proteins - immunology Mutant Proteins - isolation & purification Mutation Pasteurella Pasteurella Infections - prevention & control Pasteurella Infections - veterinary Pasteurella multocida Pasteurella multocida - genetics Pasteurella multocida - immunology Pasteurella multocida - pathogenicity Plasmids Poultry Poultry Diseases - prevention & control Protective antigen Proteins Public health Recombinant proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - isolation & purification Sepsis Vaccines Vaccines, Synthetic - immunology Veterinary Science Vibrio cholerae Virulence Virulence (Microbiology) Virulence factors Virulence Factors - genetics Virulence Factors - immunology Virulence Factors - isolation & purification Waterborne diseases
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