Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection

Cytotoxic CD8(+) T cells (CTLs) contain virus infections through the release of granules containing both perforin and granzymes. T cell 'exhaustion' is a hallmark of chronic persistent viral infections including HIV. The inhibitory regulatory molecule, T cell Immunoglobulin and Mucin domai...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40146
Hauptverfasser:	Sakhdari, Ali, Mujib, Shariq, Vali, Bahareh, Yue, Feng Yun, MacParland, Sonya, Clayton, Kiera, Jones, Richard Bradley, Liu, Jun, Lee, Erika Yue, Benko, Erika, Kovacs, Colin, Gommerman, Jennifer, Kaul, Rupert, Ostrowski, Mario A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antibodies - immunology Antibodies - pharmacology Antiretroviral drugs Biology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Degranulation - drug effects Cell Degranulation - immunology Chronic infection Conformation Cytokines Cytotoxicity Cytotoxicity, Immunologic - drug effects Degranulation Endopeptidases Epitopes, T-Lymphocyte - immunology Exhaustion Granular materials Granzyme B Hepatitis A Virus Cellular Receptor 2 HIV HIV Infections - immunology HIV Infections - metabolism HIV-1 - immunology Human immunodeficiency virus Humans Immunophenotyping Lymphocytes Lymphocytes T Medicine Membrane Proteins - immunology Membrane Proteins - metabolism Mucin Perforin Perforin - metabolism Signal transduction Signal Transduction - drug effects Signaling T cell receptors T-Box Domain Proteins - metabolism Toxicity Viral infections Viruses
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