Multi-target drugs: the trend of drug research and development
Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to...
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| Veröffentlicht in: | PloS one 2012-06, Vol.7 (6), p.e40262-e40262 |
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| creator | Lu, Jin-Jian Pan, Wei Hu, Yuan-Jia Wang, Yi-Tao |
| description | Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future. |
| doi_str_mv | 10.1371/journal.pone.0040262 |
| format | Article |
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In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0040262</identifier><identifier>PMID: 22768266</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alzheimer's disease ; Angiogenesis ; Cancer therapies ; Dopamine ; Drug approval ; Drug development ; Drug discovery ; Drug Discovery - economics ; Drug Discovery - trends ; Drugs ; Functional foods & nutraceuticals ; Growth factors ; Industrial research ; Kinases ; Laboratories ; Marketing - economics ; Medicine ; Metastasis ; Natural products ; Nervous system ; Network analysis ; Parkinson's disease ; Pharmaceutical Preparations - economics ; R&D ; Research & development ; Research - economics ; Research - trends ; Studies</subject><ispartof>PloS one, 2012-06, Vol.7 (6), p.e40262-e40262</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Lu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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| subjects | Alzheimer's disease Angiogenesis Cancer therapies Dopamine Drug approval Drug development Drug discovery Drug Discovery - economics Drug Discovery - trends Drugs Functional foods & nutraceuticals Growth factors Industrial research Kinases Laboratories Marketing - economics Medicine Metastasis Natural products Nervous system Network analysis Parkinson's disease Pharmaceutical Preparations - economics R&D Research & development Research - economics Research - trends Studies |
| title | Multi-target drugs: the trend of drug research and development |
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