Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells

The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. We have recently demonstrated that the IGF-IR is overexpressed in invasive bladder cancer tissues and promotes motility and invasion of ur...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e40148
Hauptverfasser:	Genua, Marco, Xu, Shi-Qiong, Buraschi, Simone, Peiper, Stephen C, Gomella, Leonard G, Belfiore, Antonino, Iozzo, Renato V, Morrione, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antigens Apoptosis Biology Biomarkers Bladder Bladder cancer Breast cancer Cancer Carcinoma Carcinoma - enzymology Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell cycle Cell growth Cell Line, Tumor Cell Movement - genetics Diagnostic systems Endocrinology Fibroblasts Focal adhesion kinase Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Focal Adhesion Kinase 2 - genetics Focal Adhesion Kinase 2 - metabolism Focal Adhesions - genetics Focal Adhesions - metabolism Genetic transformation GRB2 Adaptor Protein - genetics GRB2 Adaptor Protein - metabolism Homology Humans Immunofluorescence Insulin Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Invasiveness Kinases Localization MAP kinase Medical prognosis Medicine Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Motility Neoplasm Invasiveness Nuclei Pathology Paxillin Paxillin - genetics Paxillin - metabolism Phenols (Class of compounds) Proline Proline-rich tyrosine kinase 2 Prostate cancer Protein-tyrosine kinase Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Rodents Signal Transduction - genetics Signaling Tissues Transformation Tumors Tyrosine Urinary bladder Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urology Urothelial cancer Urothelial carcinoma Urothelium - enzymology Urothelium - metabolism Urothelium - pathology
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