Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice
We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60-70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the inf...
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| creator | Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi |
| description | We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60-70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance. |
| doi_str_mv | 10.1371/journal.pone.0039807 |
| format | Article |
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LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0039807</identifier><identifier>PMID: 22768129</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aging ; Animals ; Balance ; Biology ; Cell Count ; Chronic exposure ; Ears & hearing ; Electrical Equipment and Supplies ; Engineering ; Environmental Exposure ; Environmental health ; Exposure ; Gait - physiology ; Hair cells ; Hair Cells, Vestibular - pathology ; Health sciences ; Hearing loss ; Humans ; LF noise ; Medicine ; Mice ; Mice, Inbred ICR ; Molecular biology ; Noise ; Noise levels ; Organs ; Oxidative Stress ; Physiology ; Postural Balance - physiology ; Rotarod Performance Test ; Sound pressure ; Studies ; Toxicology ; Vestibular system ; Young adults</subject><ispartof>PloS one, 2012-06, Vol.7 (6), p.e39807</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Tamura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Tamura et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-2f9c3eea9a8254bc408d39ddb543eb2a3bf0f22c27570e9ed22a211d223cfb303</citedby><cites>FETCH-LOGICAL-c758t-2f9c3eea9a8254bc408d39ddb543eb2a3bf0f22c27570e9ed22a211d223cfb303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22768129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chapouthier, Georges</contributor><creatorcontrib>Tamura, Haruka</creatorcontrib><creatorcontrib>Ohgami, Nobutaka</creatorcontrib><creatorcontrib>Yajima, Ichiro</creatorcontrib><creatorcontrib>Iida, Machiko</creatorcontrib><creatorcontrib>Ohgami, Kyoko</creatorcontrib><creatorcontrib>Fujii, Noriko</creatorcontrib><creatorcontrib>Itabe, Hiroyuki</creatorcontrib><creatorcontrib>Kusudo, Tastuya</creatorcontrib><creatorcontrib>Yamashita, Hitoshi</creatorcontrib><creatorcontrib>Kato, Masashi</creatorcontrib><title>Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60-70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.</description><subject>Aging</subject><subject>Animals</subject><subject>Balance</subject><subject>Biology</subject><subject>Cell Count</subject><subject>Chronic exposure</subject><subject>Ears & hearing</subject><subject>Electrical Equipment and Supplies</subject><subject>Engineering</subject><subject>Environmental Exposure</subject><subject>Environmental health</subject><subject>Exposure</subject><subject>Gait - physiology</subject><subject>Hair cells</subject><subject>Hair Cells, Vestibular - pathology</subject><subject>Health sciences</subject><subject>Hearing loss</subject><subject>Humans</subject><subject>LF noise</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular biology</subject><subject>Noise</subject><subject>Noise levels</subject><subject>Organs</subject><subject>Oxidative Stress</subject><subject>Physiology</subject><subject>Postural Balance - 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LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22768129</pmid><doi>10.1371/journal.pone.0039807</doi><tpages>e39807</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Animals Balance Biology Cell Count Chronic exposure Ears & hearing Electrical Equipment and Supplies Engineering Environmental Exposure Environmental health Exposure Gait - physiology Hair cells Hair Cells, Vestibular - pathology Health sciences Hearing loss Humans LF noise Medicine Mice Mice, Inbred ICR Molecular biology Noise Noise levels Organs Oxidative Stress Physiology Postural Balance - physiology Rotarod Performance Test Sound pressure Studies Toxicology Vestibular system Young adults |
| title | Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice |
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