N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells

Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre. Mice with GCN5-deficient NSC exhibit a 25% reduction in brain mass with a microcephaly phenotype similar t...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39456-e39456
Hauptverfasser:	Martínez-Cerdeño, Verónica, Lemen, Jessica M, Chan, Vanessa, Wey, Alice, Lin, Wenchu, Dent, Sharon R, Knoepfler, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Biology Brain Brain cancer Cell cycle Cell proliferation Chromatin Chromatin Immunoprecipitation DNA binding proteins Female GCN5 protein Gene expression Genes Genetic aspects Histone acetyltransferase Histones Histones - metabolism Immunohistochemistry Intermediate filament proteins Kinases Laboratories Male Medicine Metabolism Mice Microcephaly Morphogenesis Myc protein Nestin Neural stem cells Neural Stem Cells - metabolism Neuroblastoma Neurons p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism Pediatrics Physiological aspects Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Stem cell transplantation Stem cells Transcription (Genetics) Transcription factors
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