Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase

Hepatitis C is a treatment-resistant disease affecting millions of people worldwide. The hepatitis C virus (HCV) genome is a single-stranded RNA molecule. After infection of the host cell, viral RNA is translated into a polyprotein that is cleaved by host and viral proteinases into functional, struc...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40029
Hauptverfasser:	Shiryaev, Sergey A, Cheltsov, Anton V, Strongin, Alex Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antiviral agents Antiviral Agents - chemistry Antiviral Agents - therapeutic use Automation Binding sites Biology Cell Line Computer Science Crystal structure Crystallography, X-Ray Dengue fever Drug resistance Drug Resistance, Viral Enzymes FDA approval Genomes Genomics Health aspects Hepacivirus - enzymology Hepatitis Hepatitis C Hepatitis C - drug therapy Hepatitis C - enzymology Hepatitis C - genetics Hepatitis C virus Hepatocellular carcinoma Humans Infection Infectious diseases Inhibitors Investigations Lead compounds Ligands Medical research Medical treatment Medicine Molecular Dynamics Simulation Mutagenesis Mutation Mutation, Missense Optimization Peptides Proteases Proteinase Proteins Ribonucleic acid RNA RNA Helicases - antagonists & inhibitors RNA Helicases - chemistry RNA Helicases - genetics RNA Helicases - metabolism RNA polymerase Scaffolds Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - therapeutic use Structure-function relationships Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral proteins Viruses West Nile virus
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