Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells

Angiogenesis is tightly regulated through complex crosstalk between pro- and anti-angiogenic signals. High molecular weight kininogen (HK) is an endogenous protein that is proteolytically cleaved in plasma and on endothelial cell surfaces to HKa, an anti-angiogenic protein. Ferritin binds to HKa and...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40030-e40030
Hauptverfasser:	Tesfay, Lia, Huhn, Annissa J, Hatcher, Heather, Torti, Frank M, Torti, Suzy V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion AKT protein Amino Acid Motifs Analysis Angiogenesis Apoptosis Binding Biochemistry Biology Cancer Cell adhesion & migration Cell Adhesion - physiology Cell survival Cell Survival - physiology Crosstalk Diabetic retinopathy Endothelial cells Endothelium Ferritin Ferritins - metabolism Focal Adhesion Kinase 1 - metabolism Glycine Histidine Human Umbilical Vein Endothelial Cells Humans Inflammation Integrin alpha5beta1 - metabolism Integrins Kininogen, High-Molecular-Weight - metabolism Kininogens Lysine MAP Kinase Signaling System - physiology Medicine Metastasis Molecular weight Paxillin Paxillin - metabolism Protein binding Proteins Proteolysis Proto-Oncogene Proteins c-akt - metabolism Signaling Survival
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