Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys

Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis tha...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e39635-e39635
Hauptverfasser:	Friederich-Persson, Malou, Aslam, Shakil, Nordquist, Lina, Welch, William J, Wilcox, Christopher S, Palm, Fredrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenosine diphosphate Adenosine Diphosphate - genetics Adenosine Diphosphate - metabolism Adenosine monophosphate Animals Binding sites Biology Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Gene Knockdown Techniques Glucose Guanosine Diphosphate - genetics Guanosine Diphosphate - metabolism Hypertension Hypoxia Ion Channels - genetics Ion Channels - metabolism Kidney Cortex - metabolism Kidney Cortex - pathology Kidney diseases Kidneys Male Malondialdehyde Malondialdehyde - metabolism Medicine Membrane potential Membrane Potential, Mitochondrial - genetics Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial ADP, ATP Translocases - genetics Mitochondrial ADP, ATP Translocases - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mitochondrial uncoupling protein 2 Musculoskeletal system Nephrology Oxidative Stress Oxygen - metabolism Phosphorylation Physiological aspects Physiology Protein expression Proteins Purines Rats Rats, Sprague-Dawley Renal cortex Respiration Rodents siRNA Statistics Streptozocin Uncoupling Protein 2
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