PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population

Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e39037-e39037
Hauptverfasser:	Villalobos-Comparán, Marisela, Villamil-Ramírez, Hugo, Villarreal-Molina, Teresa, Larrieta-Carrasco, Elena, León-Mimila, Paola, Romero-Hidalgo, Sandra, Jacobo-Albavera, Leonor, Liceaga-Fuentes, Adriana E, Campos-Pérez, Francisco J, López-Contreras, Blanca E, Tusié-Luna, Teresa, Del Río-Navarro, Blanca E, Aguilar-Salinas, Carlos A, Canizales-Quinteros, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Adolescent Adult Adult education Adults Aged Aged, 80 and over Analysis Biology Body Mass Index Child Child health Child, Preschool Childhood obesity Children Classification Computers Diabetes Enzymes Female Gene Frequency Genes Genetic aspects Genotype Glucose Glucose - metabolism Homeostasis Humans Insulin Medicine Metabolism Mexico Middle Aged Mutation Obesity Obesity - genetics Polymorphism, Single Nucleotide Population Prevalence Proprotein Convertase 1 - genetics Risk Factors Single-nucleotide polymorphism Studies Type 2 diabetes
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