Critical epitopes in the nucleocapsid protein of SFTS virus recognized by a panel of SFTS patients derived human monoclonal antibodies

SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to the new bunyavirus infection. We have generated a combinator...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38291
Hauptverfasser:	Yu, Li, Zhang, Li, Sun, Lina, Lu, Jing, Wu, Wei, Li, Chuan, Zhang, Quanfu, Zhang, Fushun, Jin, Cong, Wang, Xianjun, Bi, Zhenqiang, Li, Dexin, Liang, Mifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antigenic determinants Antigens Biology Blotting, Western Cloning Combinatorial analysis Disease control Disease prevention Enzyme-Linked Immunosorbent Assay Enzymes Epidemics Epitope Mapping Epitopes - genetics Epitopes - immunology Fab Fever Fluorescent Antibody Technique Genes Glycoproteins Health aspects Humans Immune response (humoral) Immunization Immunoassay Immunoglobulins Infection Infections Infectious diseases Libraries Medical laboratories Medicine Mice Models, Molecular Monoclonal antibodies Mutagenesis Mutagenesis, Site-Directed Mutation N protein Neutralization Tests Nucleocapsid Proteins - immunology Nucleocapsids Pathogenesis Patients Peptide mapping Phages Phlebovirus - immunology Proteins Screening Simulation Studies Thrombocytopenia Virions Viruses
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