PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1

Protein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells are either bacterial pathogenic toxins or endogenous cellular ADP-ribosyltransferases. The latter include members o...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e37352-e37352
Hauptverfasser:	Di Paola, Simone, Micaroni, Massimo, Di Tullio, Giuseppe, Buccione, Roberto, Di Girolamo, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate ADP Ribose Transferases - metabolism ADP-ribosylation Arginine Bacteria beta Karyopherins - metabolism Biology Catalysis Cells (Biology) Deoxyribonucleic acid DNA DNA repair Electron microscopy Endoplasmic reticulum Endoplasmic Reticulum - enzymology Endoplasmic Reticulum - ultrastructure Enzymes Experiments Fluorescent Antibody Technique Humans Immunofluorescence Immunoprecipitation Lysates Mammalian cells Mammals Mass Spectrometry Mass spectroscopy Melanoma Membranes Metastasis Microscopy Microscopy, Electron Monosaccharides Morphology Nuclear Envelope - enzymology Nuclear Envelope - ultrastructure Poly(ADP-ribose) Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Post-translation Post-translational modifications Proteases Protein Structure, Tertiary Proteins Regulatory mechanisms (biology) Ribose Ribosylation Sirtuins Toxins
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