Effector CD4+ T cell expression signatures and immune-mediated disease associated genes

Genome-wide association studies (GWAS) in immune-mediated diseases have identified over 150 associated genomic loci. Many of these loci play a role in T cell responses, and regulation of T cell differentiation plays a critical role in immune-mediated diseases; however, the relationship between impli...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38510-e38510
Hauptverfasser:	Zhang, Wei, Ferguson, John, Ng, Sok Meng, Hui, Ken, Goh, Gerald, Lin, Aiping, Esplugues, Enric, Flavell, Richard A, Abraham, Clara, Zhao, Hongyu, Cho, Judy H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology CCL20 protein CD4 antigen Cell differentiation Chemokine CCL20 - immunology Comparative analysis Cytokines Differentiation (biology) Disease DNA methylation DNA microarrays Enrichment Female Gene expression Gene Expression Regulation - immunology Gene regulation Genes Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Helper cells Humans Immune System Diseases - immunology Immune System Diseases - pathology Immunological memory Inflammation Inflammatory bowel disease Interleukin 1 Interleukin-17 - immunology Loci Lymphocytes Lymphocytes T Male Medical research Medicine Memory cells Methylation Pathogenesis Psoriasis Receptors, Interleukin - immunology Receptors, Interleukin-12 - immunology Signatures T cells Th1 Cells - immunology Th1 Cells - pathology Th17 Cells - immunology Th17 Cells - pathology
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