Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer

14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role in cancer relapse and metastasis. Our results show that 14-3-3σ regulates nucl...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e38347
Hauptverfasser:	Inglés-Esteve, Julia, Morales, Mònica, Dalmases, Alba, Garcia-Carbonell, Ricard, Jené-Sanz, Alba, López-Bigas, Núria, Iglesias, Mar, Ruiz-Herguido, Cristina, Rovira, Ana, Rojo, Federico, Albanell, Joan, Gomis, Roger R, Bigas, Anna, Espinosa, Lluís
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Active Transport, Cell Nucleus Animals Apoptosis Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Cancer Cell Line, Tumor Cell Movement - genetics Clonal deletion Cluster Analysis Cytokines DNA methylation Enzyme Activation - drug effects Female Gene deletion Gene Expression Gene Expression Profiling Genomes Health sciences Hospitals Humans Informatics Medical research Medicine Metastases Metastasis Mice Multivariate analysis Neoplasm Metastasis NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB protein Nuclear transport Oncology Overexpression Pathology Prognosis Protein Binding - drug effects Restoration Signal transduction Survival Analysis Transcription, Genetic Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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