Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia
Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compa...
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| Veröffentlicht in: | PloS one 2012-05, Vol.7 (5), p.e38015-e38015 |
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| creator | Essig, Stefan von der Weid, Nicolas X Strippoli, Marie-Pierre F Rebholz, Cornelia E Michel, Gisela Rueegg, Corina S Niggli, Felix K Kuehni, Claudia E |
| description | Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.
As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age |
| doi_str_mv | 10.1371/journal.pone.0038015 |
| format | Article |
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As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.
Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0038015</identifier><identifier>PMID: 22662262</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute lymphatic leukemia ; Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Adolescent ; Analysis ; Cancer ; Cancer therapies ; Child ; Child, Preschool ; Childhood ; Children ; Data processing ; Ethics ; Female ; Health ; Health risk assessment ; Health screening ; Humans ; Infant ; Infant, Newborn ; Leukemia ; Lymphatic leukemia ; Male ; Medical diagnosis ; Medicine ; Mental health ; Nervous system ; Norms ; Oncology ; Pediatrics ; Population ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - psychology ; Preventive medicine ; Quality of Life ; Quantitative psychology ; Questionnaires ; Recurrence ; Recurrence (Disease) ; Stem cell transplantation ; Studies ; Surveys ; Surveys and Questionnaires ; Survivors - psychology ; Switzerland ; Tumors</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e38015-e38015</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Essig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Essig et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5427f9f6fe760ea652052a50be394877ff30f2fdfe8c1077113af1d7ceace49d3</citedby><cites>FETCH-LOGICAL-c692t-5427f9f6fe760ea652052a50be394877ff30f2fdfe8c1077113af1d7ceace49d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360640/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360640/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22662262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Essig, Stefan</creatorcontrib><creatorcontrib>von der Weid, Nicolas X</creatorcontrib><creatorcontrib>Strippoli, Marie-Pierre F</creatorcontrib><creatorcontrib>Rebholz, Cornelia E</creatorcontrib><creatorcontrib>Michel, Gisela</creatorcontrib><creatorcontrib>Rueegg, Corina S</creatorcontrib><creatorcontrib>Niggli, Felix K</creatorcontrib><creatorcontrib>Kuehni, Claudia E</creatorcontrib><creatorcontrib>Swiss Pediatric Oncology Group (SPOG)</creatorcontrib><creatorcontrib>for the Swiss Pediatric Oncology Group (SPOG)</creatorcontrib><title>Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.
As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.
Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.</description><subject>Acute lymphatic leukemia</subject><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Adolescent</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Data processing</subject><subject>Ethics</subject><subject>Female</subject><subject>Health</subject><subject>Health risk assessment</subject><subject>Health screening</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Leukemia</subject><subject>Lymphatic leukemia</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Mental health</subject><subject>Nervous system</subject><subject>Norms</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Population</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - psychology</subject><subject>Preventive medicine</subject><subject>Quality of Life</subject><subject>Quantitative psychology</subject><subject>Questionnaires</subject><subject>Recurrence</subject><subject>Recurrence (Disease)</subject><subject>Stem cell transplantation</subject><subject>Studies</subject><subject>Surveys</subject><subject>Surveys and Questionnaires</subject><subject>Survivors - psychology</subject><subject>Switzerland</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11r2zAUhs3YWLtu_2BshsHYLpzpw5bsm0Ip2xooFPZ1KxT5KFamWKkkh-XfT2ncEo9eDGNspOd9z4d0suw1RjNMOf60coPvpZ1tXA8zhGiNcPUkO8UNJQUjiD49-j_JXoSwQqiiNWPPsxNCGEsvOc26K5A2doUHKyO0-e0grYm73OncGg256XPr-mURwa_zMPit2Tof9tt7xSYkieqMbTvn2lyqIUJud-tN5xZWhmhUbmH4DWsjX2bPtLQBXo3fs-znl88_Lq-K65uv88uL60KxhsSiKgnXjWYaOEMgWUVQRWSFFkCbsuZca4o00a2GWmHEOcZUatxyBVJB2bT0LHt78N1YF8TYpCAwJRUiBNMmEfMD0Tq5Ehtv1tLvhJNG3C04vxTSp9QtCMxlSoek2JyXtGzrStYM8bJlKqWBSfI6H6MNizW0CvropZ2YTnd604ml2wpKGWIlSgYfRgPvbgcIUaxNUGCt7MENKW9EakRSpTSh7_5BH69upJYyFWB67VJctTcVFyXnqMS8womaPUKlp01npdKN0iatTwQfJ4LERPgTl3IIQcy_f_t_9ubXlH1_xHZ3lzE4O0Tj-jAFywOovAvBg35oMkZiPxD33RD7gRDjQCTZm-MDehDdTwD9Cy7qBec</recordid><startdate>20120525</startdate><enddate>20120525</enddate><creator>Essig, Stefan</creator><creator>von der Weid, Nicolas X</creator><creator>Strippoli, Marie-Pierre F</creator><creator>Rebholz, Cornelia E</creator><creator>Michel, Gisela</creator><creator>Rueegg, Corina S</creator><creator>Niggli, Felix K</creator><creator>Kuehni, Claudia E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120525</creationdate><title>Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia</title><author>Essig, Stefan ; von der Weid, Nicolas X ; Strippoli, Marie-Pierre F ; Rebholz, Cornelia E ; Michel, Gisela ; Rueegg, Corina S ; Niggli, Felix K ; Kuehni, Claudia E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-5427f9f6fe760ea652052a50be394877ff30f2fdfe8c1077113af1d7ceace49d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute lymphatic leukemia</topic><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Adolescent</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Data processing</topic><topic>Ethics</topic><topic>Female</topic><topic>Health</topic><topic>Health risk assessment</topic><topic>Health screening</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Leukemia</topic><topic>Lymphatic leukemia</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Mental health</topic><topic>Nervous system</topic><topic>Norms</topic><topic>Oncology</topic><topic>Pediatrics</topic><topic>Population</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - 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Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.
As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.
Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22662262</pmid><doi>10.1371/journal.pone.0038015</doi><tpages>e38015</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute lymphatic leukemia Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Analysis Cancer Cancer therapies Child Child, Preschool Childhood Children Data processing Ethics Female Health Health risk assessment Health screening Humans Infant Infant, Newborn Leukemia Lymphatic leukemia Male Medical diagnosis Medicine Mental health Nervous system Norms Oncology Pediatrics Population Precursor Cell Lymphoblastic Leukemia-Lymphoma - psychology Preventive medicine Quality of Life Quantitative psychology Questionnaires Recurrence Recurrence (Disease) Stem cell transplantation Studies Surveys Surveys and Questionnaires Survivors - psychology Switzerland Tumors |
| title | Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia |
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