Autonomic function following acute organophosphorus poisoning: a cohort study
Autonomic dysfunction after chronic low level exposure to organophosphorus (OP) pesticides has been consistently reported in the literature, but not following a single acute overdose. In order to study autonomic function after an acute OP overdose, sixty-six overdose patients were compared to 70 mat...
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| description | Autonomic dysfunction after chronic low level exposure to organophosphorus (OP) pesticides has been consistently reported in the literature, but not following a single acute overdose. In order to study autonomic function after an acute OP overdose, sixty-six overdose patients were compared to 70 matched controls. Assessment of autonomic function was done by heart rate response to standing, deep breathing (HR-DB) and Valsalva manoeuvre; blood pressure (BP) response to standing and sustained hand grip; amplitude and latency of sympathetic skin response (SSR); pupil size and post-void urine volume. The patients were assessed one and six weeks after the exposure. The number of patients who showed abnormal autonomic function compared to standard cut-off values did not show statistically significantly difference from that of controls by Chi-Square test. When compared to the controls at one week the only significant differences consistent with autonomic dysfunction were change of diastolic BP 3 min after standing, HR-DB, SSR-Amplitude, SSR-Latency, post-void urine volume and size of the pupil. At 6 weeks significant recovery of autonomic function was observed and only HR-DB was decreased to a minor degree, -5 beats/min [95%CI 2-8]. This study provides good evidence for the lack of long term autonomic dysfunction following acute exposure to OP pesticides. |
| doi_str_mv | 10.1371/journal.pone.0037987 |
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In order to study autonomic function after an acute OP overdose, sixty-six overdose patients were compared to 70 matched controls. Assessment of autonomic function was done by heart rate response to standing, deep breathing (HR-DB) and Valsalva manoeuvre; blood pressure (BP) response to standing and sustained hand grip; amplitude and latency of sympathetic skin response (SSR); pupil size and post-void urine volume. The patients were assessed one and six weeks after the exposure. The number of patients who showed abnormal autonomic function compared to standard cut-off values did not show statistically significantly difference from that of controls by Chi-Square test. When compared to the controls at one week the only significant differences consistent with autonomic dysfunction were change of diastolic BP 3 min after standing, HR-DB, SSR-Amplitude, SSR-Latency, post-void urine volume and size of the pupil. At 6 weeks significant recovery of autonomic function was observed and only HR-DB was decreased to a minor degree, -5 beats/min [95%CI 2-8]. This study provides good evidence for the lack of long term autonomic dysfunction following acute exposure to OP pesticides.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0037987</identifier><identifier>PMID: 22655091</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Agriculture ; Agrochemicals ; Alcohol use ; Autonomic nervous system ; Autonomic Nervous System - drug effects ; Autonomic Nervous System - physiopathology ; Autonomic Nervous System Diseases - chemically induced ; Autonomic Nervous System Diseases - physiopathology ; Biology ; Blood pressure ; Blood Pressure - drug effects ; Breathing ; Cohort analysis ; Cohort Studies ; Comparative analysis ; Diabetes ; Exposure ; Farmworkers ; Female ; Hand Strength ; Health risk assessment ; Heart rate ; Heart Rate - drug effects ; Humans ; Insecticides ; Latency ; Low level ; Male ; Medical research ; Medicine ; Middle Aged ; Neurophysiology ; Neurosciences ; Organophosphate Poisoning ; Overdose ; Patients ; Pesticides ; Pesticides - poisoning ; Poisoning ; Posture ; Pupil - drug effects ; Pupil size ; Respiration - drug effects ; Skin ; Statistical tests ; Studies ; Sympathetic nervous system ; Ultrasonic imaging ; Urine ; Valsalva Maneuver - drug effects ; Young Adult</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e37987</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Jayasinghe, Pathirana. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In order to study autonomic function after an acute OP overdose, sixty-six overdose patients were compared to 70 matched controls. Assessment of autonomic function was done by heart rate response to standing, deep breathing (HR-DB) and Valsalva manoeuvre; blood pressure (BP) response to standing and sustained hand grip; amplitude and latency of sympathetic skin response (SSR); pupil size and post-void urine volume. The patients were assessed one and six weeks after the exposure. The number of patients who showed abnormal autonomic function compared to standard cut-off values did not show statistically significantly difference from that of controls by Chi-Square test. When compared to the controls at one week the only significant differences consistent with autonomic dysfunction were change of diastolic BP 3 min after standing, HR-DB, SSR-Amplitude, SSR-Latency, post-void urine volume and size of the pupil. At 6 weeks significant recovery of autonomic function was observed and only HR-DB was decreased to a minor degree, -5 beats/min [95%CI 2-8]. This study provides good evidence for the lack of long term autonomic dysfunction following acute exposure to OP pesticides.</description><subject>Adult</subject><subject>Agriculture</subject><subject>Agrochemicals</subject><subject>Alcohol use</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Autonomic Nervous System Diseases - chemically induced</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Biology</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Breathing</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comparative analysis</subject><subject>Diabetes</subject><subject>Exposure</subject><subject>Farmworkers</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Health risk assessment</subject><subject>Heart rate</subject><subject>Heart Rate - 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In order to study autonomic function after an acute OP overdose, sixty-six overdose patients were compared to 70 matched controls. Assessment of autonomic function was done by heart rate response to standing, deep breathing (HR-DB) and Valsalva manoeuvre; blood pressure (BP) response to standing and sustained hand grip; amplitude and latency of sympathetic skin response (SSR); pupil size and post-void urine volume. The patients were assessed one and six weeks after the exposure. The number of patients who showed abnormal autonomic function compared to standard cut-off values did not show statistically significantly difference from that of controls by Chi-Square test. When compared to the controls at one week the only significant differences consistent with autonomic dysfunction were change of diastolic BP 3 min after standing, HR-DB, SSR-Amplitude, SSR-Latency, post-void urine volume and size of the pupil. At 6 weeks significant recovery of autonomic function was observed and only HR-DB was decreased to a minor degree, -5 beats/min [95%CI 2-8]. This study provides good evidence for the lack of long term autonomic dysfunction following acute exposure to OP pesticides.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22655091</pmid><doi>10.1371/journal.pone.0037987</doi><tpages>e37987</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Agriculture Agrochemicals Alcohol use Autonomic nervous system Autonomic Nervous System - drug effects Autonomic Nervous System - physiopathology Autonomic Nervous System Diseases - chemically induced Autonomic Nervous System Diseases - physiopathology Biology Blood pressure Blood Pressure - drug effects Breathing Cohort analysis Cohort Studies Comparative analysis Diabetes Exposure Farmworkers Female Hand Strength Health risk assessment Heart rate Heart Rate - drug effects Humans Insecticides Latency Low level Male Medical research Medicine Middle Aged Neurophysiology Neurosciences Organophosphate Poisoning Overdose Patients Pesticides Pesticides - poisoning Poisoning Posture Pupil - drug effects Pupil size Respiration - drug effects Skin Statistical tests Studies Sympathetic nervous system Ultrasonic imaging Urine Valsalva Maneuver - drug effects Young Adult |
| title | Autonomic function following acute organophosphorus poisoning: a cohort study |
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