AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis

We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU). In this study we investigated whether subretinal injection of both AVV2.IFN-α and AAV2.IL-4 had a stronger i...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e37995-e37995
Hauptverfasser:	Tian, Lichun, Lei, Bo, Shao, Ju, Wei, Lin, Kijlstra, Aize, Yang, Peizeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoimmune Diseases - therapy Biology Cytokines Dependovirus - genetics Disease Disease Models, Animal Experimental autoimmune uveoretinitis Eye (anatomy) Fluorescence Gene therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - genetics Green fluorescent protein Hospitals Humans Hypersensitivity Hypersensitivity (delayed) Immune response Immune system Inflammation Injection Interferon Interferon-alpha - genetics Interferon-alpha - metabolism Interleukin 17 Interleukin 4 Interleukin-4 - genetics Interleukin-4 - metabolism Laboratories Lymphatic system Lymphocytes Medicine Melanoma Metastasis Mice Recombinant Proteins - genetics Recombinant Proteins - metabolism Respiratory diseases Retina Retina - metabolism Retina - pathology Severity of Illness Index Studies Treatment Outcome Tumor necrosis factor-TNF Uveitis - genetics Uveitis - metabolism Uveitis - therapy Viruses α-Interferon
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