Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction

The p53 transcription factor and tumor suppressor is regulated primarily by the E3 ubiquitin ligase Mdm2, which ubiquitinates p53 to target it for proteasomal degradation. Aside from its ubiquitin ligase function, Mdm2 has been believed to be capable of suppressing p53's transcriptional activit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e38212-e38212
Hauptverfasser:	Clegg, Hilary V, Itahana, Yoko, Itahana, Koji, Ramalingam, Sundhar, Zhang, Yanping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Alanine Animals Bax protein Binding Biology Biosynthesis Cancer Cell cycle Cell growth Cell Line Chemotherapy Cyclin-Dependent Kinase Inhibitor p21 - genetics Cysteine Deoxyribonucleic acid DNA E1A-Associated p300 Protein - metabolism Embryo fibroblasts Embryos Event-related potentials Fibroblasts Gene mutation Genetic aspects Homology Inhibition Ligases Masking MDM2 protein Medicine Mice Mutation Oncology p53 Protein Phosphorylation Point mutation Promoter Regions, Genetic - genetics Proteasomes Protein Binding Proteins Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism RING Finger Domains - genetics Stem cells Transcription (Genetics) Transcription, Genetic Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Ubiquitin Ubiquitin-protein ligase Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!