Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA
An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown. The objective of this study was to investigate the influence of prenatal As exposure on globa...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-05, Vol.7 (5), p.e37147 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e37147 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Pilsner, J Richard Hall, Megan N Liu, Xinhua Ilievski, Vesna Slavkovich, Vesna Levy, Diane Factor-Litvak, Pam Yunus, Mahammad Rahman, Mahfuzar Graziano, Joseph H Gamble, Mary V |
| description | An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.
The objective of this study was to investigate the influence of prenatal As exposure on global methylation of cord blood DNA in a study of mother/newborn pairs in Matlab, Bangladesh.
Maternal and cord blood DNA were available from a convenience sample of 101 mother/newborn pairs. Measures of As exposure included maternal urinary As (uAs), maternal blood As (mbAs) and cord blood As (cbAs). Several measures of global DNA methylation were assessed, including the [3H]-methyl-incorporation assay and three Pyrosequencing assays: Alu, LINE-1 and LUMA.
In the total sample, increasing quartiles of maternal uAs were associated with an increase in covariate-adjusted means of newborn global DNA methylation as measured by the [3H]-methyl-incorporation assay (quartile 1 (Q1) and Q2 vs. Q4; p = 0.06 and 0.04, respectively). Sex-specific linear regression analyses, while not reaching significance level of 0.05, indicated that the associations between As exposures and Alu, LINE-1 and LUMA were positive among male newborns (N = 58) but negative among female newborns (N = 43); tests for sex differences were borderline significant for the association of cbAs and mbAs with Alu (p = 0.05 and 0.09, respectively) and for the association between maternal uAs and LINE-1 (p = 0.07). Sex-specific correlations between maternal urinary creatinine and newborn methyl-incorporation, Alu and LINE-1 were also evident (p |
| doi_str_mv | 10.1371/journal.pone.0037147 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1325012806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477041768</galeid><doaj_id>oai_doaj_org_article_08ad313a29c1452981ae014fc7c1547f</doaj_id><sourcerecordid>A477041768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-33b0a8e391fd6e441815868f4b77e5411b4fd086d3e0bb7443a0c33c9825df9f3</originalsourceid><addsrcrecordid>eNqNkl2LEzEUhgdR3HX1H4gOCIIXrckkk2RuFsr6VVhc8OvSkElO2lnSpCYz2v33pnZ26YCC5CLhzXPeczi8RfEUozkmHL--DkP0ys23wcMcoSxRfq84xQ2pZqxC5P7R-6R4lNI1QjURjD0sTqqKsQoTelp8X3rrBvAaymDLbQSveuVKFRP4Tpew24Y0RCiVN6WHX22IvkywK4MvVy60Gd1Av75xqu-ylC10iKZsXQimfPNx8bh4YJVL8GS8z4qv795-ufgwu7x6v7xYXM40r0U_I6RFSgBpsDUMKMUC14IJS1vOoaYYt9QaJJghgNqWU0oU0oToRlS1sY0lZ8Xzg-_WhSTH1SSJSVUjXAnEMrE8ECaoa7mN3UbFGxlUJ_8IIa6kin2nHUgklCGYqKrRmNZVI7AChKnVXOOa8n2387Hb0G7AaPB9VG5iOv3x3Vquwk9JCEOsEdngxWgQw48BUv-PkUdqpfJUnbchm-lNl7RcUM4RxZztveZ_ofIxsOl0Doftsj4peDUpyEwPu36lhpTk8vOn_2evvk3Zl0fsGpTr1ym4YZ-MNAXpAdQxpBTB3m0OI7nP9u025D7bcsx2Lnt2vPW7otswk99jbfMs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1325012806</pqid></control><display><type>article</type><title>Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Pilsner, J Richard ; Hall, Megan N ; Liu, Xinhua ; Ilievski, Vesna ; Slavkovich, Vesna ; Levy, Diane ; Factor-Litvak, Pam ; Yunus, Mahammad ; Rahman, Mahfuzar ; Graziano, Joseph H ; Gamble, Mary V</creator><creatorcontrib>Pilsner, J Richard ; Hall, Megan N ; Liu, Xinhua ; Ilievski, Vesna ; Slavkovich, Vesna ; Levy, Diane ; Factor-Litvak, Pam ; Yunus, Mahammad ; Rahman, Mahfuzar ; Graziano, Joseph H ; Gamble, Mary V</creatorcontrib><description>An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.
The objective of this study was to investigate the influence of prenatal As exposure on global methylation of cord blood DNA in a study of mother/newborn pairs in Matlab, Bangladesh.
Maternal and cord blood DNA were available from a convenience sample of 101 mother/newborn pairs. Measures of As exposure included maternal urinary As (uAs), maternal blood As (mbAs) and cord blood As (cbAs). Several measures of global DNA methylation were assessed, including the [3H]-methyl-incorporation assay and three Pyrosequencing assays: Alu, LINE-1 and LUMA.
In the total sample, increasing quartiles of maternal uAs were associated with an increase in covariate-adjusted means of newborn global DNA methylation as measured by the [3H]-methyl-incorporation assay (quartile 1 (Q1) and Q2 vs. Q4; p = 0.06 and 0.04, respectively). Sex-specific linear regression analyses, while not reaching significance level of 0.05, indicated that the associations between As exposures and Alu, LINE-1 and LUMA were positive among male newborns (N = 58) but negative among female newborns (N = 43); tests for sex differences were borderline significant for the association of cbAs and mbAs with Alu (p = 0.05 and 0.09, respectively) and for the association between maternal uAs and LINE-1 (p = 0.07). Sex-specific correlations between maternal urinary creatinine and newborn methyl-incorporation, Alu and LINE-1 were also evident (p<0.05).
These results suggest that prenatal As exposure is associated with global DNA methylation in cord blood DNA, possibly in a sex-specific manner. Arsenic-induced epigenetic modifications in utero may potentially influence disease outcomes later in life. Additional studies are needed to confirm these findings and to examine the persistence of DNA methylation marks over time.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0037147</identifier><identifier>PMID: 22662134</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alu Elements ; Analysis ; Aquifers ; Arsenic ; Arsenic - toxicity ; Assaying ; Biology ; Biomarkers ; Blood ; Blood Cells - metabolism ; Cancer ; Cord blood ; Creatinine ; Deoxyribonucleic acid ; Disease ; DNA ; DNA methylation ; DNA Methylation - drug effects ; Drinking water ; Environmental health ; Enzymes ; Epidemiology ; Epigenetic inheritance ; Epigenetics ; Exposure ; Female ; Fetal Blood ; Gender aspects ; Gene expression ; Genetic research ; Genomes ; Health sciences ; Humans ; Infant, Newborn ; Inuit ; Long Interspersed Nucleotide Elements ; Male ; Maternal Exposure ; Medical research ; Medicine ; Metabolism ; Methylation ; Neonates ; Newborn babies ; Newborn infants ; Pregnancy ; Pregnant women ; Prenatal experience ; Prevention ; Public health ; Quartiles ; Regression analysis ; Sex ; Sex differences ; Sex Factors ; Studies ; Tumors ; Umbilical cord ; Womens health ; Young Adult</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e37147</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Pilsner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Pilsner et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-33b0a8e391fd6e441815868f4b77e5411b4fd086d3e0bb7443a0c33c9825df9f3</citedby><cites>FETCH-LOGICAL-c758t-33b0a8e391fd6e441815868f4b77e5411b4fd086d3e0bb7443a0c33c9825df9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360698/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360698/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22662134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilsner, J Richard</creatorcontrib><creatorcontrib>Hall, Megan N</creatorcontrib><creatorcontrib>Liu, Xinhua</creatorcontrib><creatorcontrib>Ilievski, Vesna</creatorcontrib><creatorcontrib>Slavkovich, Vesna</creatorcontrib><creatorcontrib>Levy, Diane</creatorcontrib><creatorcontrib>Factor-Litvak, Pam</creatorcontrib><creatorcontrib>Yunus, Mahammad</creatorcontrib><creatorcontrib>Rahman, Mahfuzar</creatorcontrib><creatorcontrib>Graziano, Joseph H</creatorcontrib><creatorcontrib>Gamble, Mary V</creatorcontrib><title>Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.
The objective of this study was to investigate the influence of prenatal As exposure on global methylation of cord blood DNA in a study of mother/newborn pairs in Matlab, Bangladesh.
Maternal and cord blood DNA were available from a convenience sample of 101 mother/newborn pairs. Measures of As exposure included maternal urinary As (uAs), maternal blood As (mbAs) and cord blood As (cbAs). Several measures of global DNA methylation were assessed, including the [3H]-methyl-incorporation assay and three Pyrosequencing assays: Alu, LINE-1 and LUMA.
In the total sample, increasing quartiles of maternal uAs were associated with an increase in covariate-adjusted means of newborn global DNA methylation as measured by the [3H]-methyl-incorporation assay (quartile 1 (Q1) and Q2 vs. Q4; p = 0.06 and 0.04, respectively). Sex-specific linear regression analyses, while not reaching significance level of 0.05, indicated that the associations between As exposures and Alu, LINE-1 and LUMA were positive among male newborns (N = 58) but negative among female newborns (N = 43); tests for sex differences were borderline significant for the association of cbAs and mbAs with Alu (p = 0.05 and 0.09, respectively) and for the association between maternal uAs and LINE-1 (p = 0.07). Sex-specific correlations between maternal urinary creatinine and newborn methyl-incorporation, Alu and LINE-1 were also evident (p<0.05).
These results suggest that prenatal As exposure is associated with global DNA methylation in cord blood DNA, possibly in a sex-specific manner. Arsenic-induced epigenetic modifications in utero may potentially influence disease outcomes later in life. Additional studies are needed to confirm these findings and to examine the persistence of DNA methylation marks over time.</description><subject>Adult</subject><subject>Alu Elements</subject><subject>Analysis</subject><subject>Aquifers</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Assaying</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood Cells - metabolism</subject><subject>Cancer</subject><subject>Cord blood</subject><subject>Creatinine</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Methylation - drug effects</subject><subject>Drinking water</subject><subject>Environmental health</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Exposure</subject><subject>Female</subject><subject>Fetal Blood</subject><subject>Gender aspects</subject><subject>Gene expression</subject><subject>Genetic research</subject><subject>Genomes</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Inuit</subject><subject>Long Interspersed Nucleotide Elements</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Methylation</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal experience</subject><subject>Prevention</subject><subject>Public health</subject><subject>Quartiles</subject><subject>Regression analysis</subject><subject>Sex</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Tumors</subject><subject>Umbilical cord</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEUhgdR3HX1H4gOCIIXrckkk2RuFsr6VVhc8OvSkElO2lnSpCYz2v33pnZ26YCC5CLhzXPeczi8RfEUozkmHL--DkP0ys23wcMcoSxRfq84xQ2pZqxC5P7R-6R4lNI1QjURjD0sTqqKsQoTelp8X3rrBvAaymDLbQSveuVKFRP4Tpew24Y0RCiVN6WHX22IvkywK4MvVy60Gd1Av75xqu-ylC10iKZsXQimfPNx8bh4YJVL8GS8z4qv795-ufgwu7x6v7xYXM40r0U_I6RFSgBpsDUMKMUC14IJS1vOoaYYt9QaJJghgNqWU0oU0oToRlS1sY0lZ8Xzg-_WhSTH1SSJSVUjXAnEMrE8ECaoa7mN3UbFGxlUJ_8IIa6kin2nHUgklCGYqKrRmNZVI7AChKnVXOOa8n2387Hb0G7AaPB9VG5iOv3x3Vquwk9JCEOsEdngxWgQw48BUv-PkUdqpfJUnbchm-lNl7RcUM4RxZztveZ_ofIxsOl0Doftsj4peDUpyEwPu36lhpTk8vOn_2evvk3Zl0fsGpTr1ym4YZ-MNAXpAdQxpBTB3m0OI7nP9u025D7bcsx2Lnt2vPW7otswk99jbfMs</recordid><startdate>20120525</startdate><enddate>20120525</enddate><creator>Pilsner, J Richard</creator><creator>Hall, Megan N</creator><creator>Liu, Xinhua</creator><creator>Ilievski, Vesna</creator><creator>Slavkovich, Vesna</creator><creator>Levy, Diane</creator><creator>Factor-Litvak, Pam</creator><creator>Yunus, Mahammad</creator><creator>Rahman, Mahfuzar</creator><creator>Graziano, Joseph H</creator><creator>Gamble, Mary V</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120525</creationdate><title>Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA</title><author>Pilsner, J Richard ; Hall, Megan N ; Liu, Xinhua ; Ilievski, Vesna ; Slavkovich, Vesna ; Levy, Diane ; Factor-Litvak, Pam ; Yunus, Mahammad ; Rahman, Mahfuzar ; Graziano, Joseph H ; Gamble, Mary V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-33b0a8e391fd6e441815868f4b77e5411b4fd086d3e0bb7443a0c33c9825df9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Alu Elements</topic><topic>Analysis</topic><topic>Aquifers</topic><topic>Arsenic</topic><topic>Arsenic - toxicity</topic><topic>Assaying</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood Cells - metabolism</topic><topic>Cancer</topic><topic>Cord blood</topic><topic>Creatinine</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA Methylation - drug effects</topic><topic>Drinking water</topic><topic>Environmental health</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Exposure</topic><topic>Female</topic><topic>Fetal Blood</topic><topic>Gender aspects</topic><topic>Gene expression</topic><topic>Genetic research</topic><topic>Genomes</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Inuit</topic><topic>Long Interspersed Nucleotide Elements</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Methylation</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Newborn infants</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Prenatal experience</topic><topic>Prevention</topic><topic>Public health</topic><topic>Quartiles</topic><topic>Regression analysis</topic><topic>Sex</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Studies</topic><topic>Tumors</topic><topic>Umbilical cord</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilsner, J Richard</creatorcontrib><creatorcontrib>Hall, Megan N</creatorcontrib><creatorcontrib>Liu, Xinhua</creatorcontrib><creatorcontrib>Ilievski, Vesna</creatorcontrib><creatorcontrib>Slavkovich, Vesna</creatorcontrib><creatorcontrib>Levy, Diane</creatorcontrib><creatorcontrib>Factor-Litvak, Pam</creatorcontrib><creatorcontrib>Yunus, Mahammad</creatorcontrib><creatorcontrib>Rahman, Mahfuzar</creatorcontrib><creatorcontrib>Graziano, Joseph H</creatorcontrib><creatorcontrib>Gamble, Mary V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilsner, J Richard</au><au>Hall, Megan N</au><au>Liu, Xinhua</au><au>Ilievski, Vesna</au><au>Slavkovich, Vesna</au><au>Levy, Diane</au><au>Factor-Litvak, Pam</au><au>Yunus, Mahammad</au><au>Rahman, Mahfuzar</au><au>Graziano, Joseph H</au><au>Gamble, Mary V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-05-25</date><risdate>2012</risdate><volume>7</volume><issue>5</issue><spage>e37147</spage><pages>e37147-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.
The objective of this study was to investigate the influence of prenatal As exposure on global methylation of cord blood DNA in a study of mother/newborn pairs in Matlab, Bangladesh.
Maternal and cord blood DNA were available from a convenience sample of 101 mother/newborn pairs. Measures of As exposure included maternal urinary As (uAs), maternal blood As (mbAs) and cord blood As (cbAs). Several measures of global DNA methylation were assessed, including the [3H]-methyl-incorporation assay and three Pyrosequencing assays: Alu, LINE-1 and LUMA.
In the total sample, increasing quartiles of maternal uAs were associated with an increase in covariate-adjusted means of newborn global DNA methylation as measured by the [3H]-methyl-incorporation assay (quartile 1 (Q1) and Q2 vs. Q4; p = 0.06 and 0.04, respectively). Sex-specific linear regression analyses, while not reaching significance level of 0.05, indicated that the associations between As exposures and Alu, LINE-1 and LUMA were positive among male newborns (N = 58) but negative among female newborns (N = 43); tests for sex differences were borderline significant for the association of cbAs and mbAs with Alu (p = 0.05 and 0.09, respectively) and for the association between maternal uAs and LINE-1 (p = 0.07). Sex-specific correlations between maternal urinary creatinine and newborn methyl-incorporation, Alu and LINE-1 were also evident (p<0.05).
These results suggest that prenatal As exposure is associated with global DNA methylation in cord blood DNA, possibly in a sex-specific manner. Arsenic-induced epigenetic modifications in utero may potentially influence disease outcomes later in life. Additional studies are needed to confirm these findings and to examine the persistence of DNA methylation marks over time.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22662134</pmid><doi>10.1371/journal.pone.0037147</doi><tpages>e37147</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-05, Vol.7 (5), p.e37147 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1325012806 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Alu Elements Analysis Aquifers Arsenic Arsenic - toxicity Assaying Biology Biomarkers Blood Blood Cells - metabolism Cancer Cord blood Creatinine Deoxyribonucleic acid Disease DNA DNA methylation DNA Methylation - drug effects Drinking water Environmental health Enzymes Epidemiology Epigenetic inheritance Epigenetics Exposure Female Fetal Blood Gender aspects Gene expression Genetic research Genomes Health sciences Humans Infant, Newborn Inuit Long Interspersed Nucleotide Elements Male Maternal Exposure Medical research Medicine Metabolism Methylation Neonates Newborn babies Newborn infants Pregnancy Pregnant women Prenatal experience Prevention Public health Quartiles Regression analysis Sex Sex differences Sex Factors Studies Tumors Umbilical cord Womens health Young Adult |
| title | Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T03%3A46%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20prenatal%20arsenic%20exposure%20and%20newborn%20sex%20on%20global%20methylation%20of%20cord%20blood%20DNA&rft.jtitle=PloS%20one&rft.au=Pilsner,%20J%20Richard&rft.date=2012-05-25&rft.volume=7&rft.issue=5&rft.spage=e37147&rft.pages=e37147-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0037147&rft_dat=%3Cgale_plos_%3EA477041768%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325012806&rft_id=info:pmid/22662134&rft_galeid=A477041768&rft_doaj_id=oai_doaj_org_article_08ad313a29c1452981ae014fc7c1547f&rfr_iscdi=true |