A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events

Extracellular adenosine triphosphate (ATP) regulates inflammatory cells by activation of the P2X(7) receptor. We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this hypothesis using genetic...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37491-e37491
Hauptverfasser:	Gidlöf, Olof, Smith, J Gustav, Melander, Olle, Lövkvist, Håkan, Hedblad, Bo, Engström, Gunnar, Nilsson, Peter, Carlson, Joyce, Berglund, Göran, Olsson, Sandra, Jood, Katarina, Jern, Christina, Norrving, Bo, Lindgren, Arne, Erlinge, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Aged Aged, 80 and over Atherogenesis atherosclerosis ATP ATP (Adenosine triphosphate) Biology Biomarkers blood-pressure Cardiac and Cardiovascular Systems Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - genetics Chromosome 12 Clinical Medicine Coronary artery disease Cytokines Diabetes disease Female gain-of-function Gene Frequency Gene Order Genes Genetic aspects genetic association Genetic Predisposition to Disease Genotype Haplotypes Health risks Heart Heart diseases human p2x receptor Humans Hypertension Inflammation Ischemia ischemic-stroke Kardiologi Kinases Klinisk medicin Linkage Disequilibrium Lymphocytes Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Middle Aged Multiple sclerosis Muscle proteins Mutation, Missense Neurosciences Physiology Polymorphism Polymorphism, Single Nucleotide Proteins Quality Control Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - metabolism Regression analysis Regression models Rehabilitation Risk Risk analysis Risk factors Signaling Single-nucleotide polymorphism Stroke Studies susceptibility Thrombosis Toxoplasma gondii Ultrasonic imaging
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