IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro

IQGAP1 is a scaffold protein that interacts with proteins of the cytoskeleton and the intercellular adhesion complex. In podocytes, IQGAP1 is associated with nephrin in the glomerular slit diaphragm (SD) complex, but its role remains ill-defined. In this work, we investigated the interaction of IQGA...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37695-e37695
Hauptverfasser:	Rigothier, Claire, Auguste, Patrick, Welsh, Gavin I, Lepreux, Sébastien, Deminière, Colette, Mathieson, Peter W, Saleem, Moin A, Ripoche, Jean, Combe, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - metabolism Adaptor Proteins, Signal Transducing - metabolism beta Catenin - metabolism Biology Cell adhesion Cell Adhesion Molecules Cell Adhesion Molecules, Neuronal - metabolism Cell culture Cell Line Cell Movement - physiology Cytoskeletal proteins Cytoskeletal Proteins - metabolism Cytoskeleton Diaphragm Diaphragm (anatomy) Epithelial cells Experiments Guanylate Kinases Humans Immunohistochemistry Immunoprecipitation Intracellular Signaling Peptides and Proteins - metabolism IQGAP1 protein Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Kidneys Localization MAGI-1 protein Medicine Membrane Proteins - metabolism Molecular weight Oncogene Proteins - metabolism Permeability Podocytes - metabolism Protein Binding Protein Transport Proteins ras GTPase-Activating Proteins - metabolism Rodents Sialoglycoproteins - metabolism Trends Vascular endothelial growth factor α-Actinin
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