Methamphetamine and inflammatory cytokines increase neuronal Na+/K+-ATPase isoform 3: relevance for HIV associated neurocognitive disorders

Methamphetamine (METH) abuse in conjunction with human immunodeficiency virus (HIV) exacerbates neuropathogenesis and accelerates neurocognitive impairments in the central nervous system (CNS), collectively termed HIV Associated Neurocognitive Disorders (HAND). Since both HIV and METH have been impl...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37604
Hauptverfasser:	Pendyala, Gurudutt, Buescher, James L, Fox, Howard S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animal cognition Animals Apoptosis Biology Brain research Caudate nucleus Cell Survival - drug effects Central nervous system Cognition Cognition Disorders - drug therapy Cognition Disorders - etiology Cognition Disorders - metabolism Cytokines Cytokines - pharmacology Disorders Drug abuse Drugs Enzyme Activation - drug effects Extracellular signal-regulated kinase Growth factors HIV HIV Infections - complications Human immunodeficiency virus Humans Infections Inflammation Kinases Laboratory animals Macaca mulatta Medicine Metabolic pathways Methamphetamine Methamphetamine - pharmacology Methamphetamine - therapeutic use Monkeys Na+/K+-exchanging ATPase Neurodegeneration Neurons Neurons - drug effects Neurons - metabolism Neuropathogenesis Phosphatase Protein Kinase Inhibitors - pharmacology Proteins Proteomics Rats Rats, Sprague-Dawley Rodents Signaling Simian Acquired Immunodeficiency Syndrome - complications Sodium-Potassium-Exchanging ATPase - metabolism Studies Substance-Related Disorders - complications Sucrose Synaptosomes Viruses
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