Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains

The HIV-1 Rev trans-activator is a nucleocytoplasmic shuttle protein that is essential for virus replication. Rev directly binds to unspliced and incompletely spliced viral RNA via the cis-acting Rev Response Element (RRE) sequence. Subsequently, Rev oligomerizes cooperatively and interacts with the...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38305-e38305
Hauptverfasser:	Hoffmann, Dirk, Schwarck, Doreen, Banning, Carina, Brenner, Matthias, Mariyanna, Lakshmikanth, Krepstakies, Marcel, Schindler, Michael, Millar, David P, Hauber, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Active Transport, Cell Nucleus Amino acids Analysis Animals Biology Blood proteins Cell Nucleus - metabolism Dimerization Exports Fluorescence Resonance Energy Transfer Gene expression Half-Life HeLa Cells HIV HIV-1 - genetics Human immunodeficiency virus Humans International trade Ligands Medicine Mice Monomers Mutation - genetics NIH 3T3 Cells Nuclear transport Nucleotide sequence Oligomerization Oligomers Packaging Phenotype Phosphatase Protein Binding Protein Multimerization Protein Structure, Quaternary Protein Structure, Tertiary Proteins Recombinant Fusion Proteins - metabolism Recruitment Response Elements - genetics rev Gene Products, Human Immunodeficiency Virus - metabolism Ribonucleic acid RNA RNA Transport RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - metabolism Trans-Activators - chemistry Trans-Activators - metabolism Transcriptional Activation - genetics Virology Viruses
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