New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease without a well-defined genetic alteration responsible for the onset of the disease. Several lines of evidence coincide in identifying stimulatory and growth signals delivered by B-cell receptor (BCR), and co-receptors together with NFkB p...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e38158-e38158
Hauptverfasser:	Doménech, Elena, Gómez-López, Gonzalo, Gzlez-Peña, Daniel, López, Mar, Herreros, Beatriz, Menezes, Juliane, Gómez-Lozano, Natalia, Carro, Angel, Graña, Osvaldo, Pisano, David G, Domínguez, Orlando, García-Marco, José A, Piris, Miguel A, Sánchez-Beato, Margarita
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Antigens B-cell receptor Biology Cell cycle Cell survival Chronic lymphocytic leukemia Deoxyribonucleic acid Disease DNA DNA Mutational Analysis Gene mutation Gene sequencing Genes Genetic aspects Genomes High-Throughput Nucleotide Sequencing - methods Humans K-Ras protein Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Lung cancer Lymphatic leukemia Lymphocytes B Lymphoma Medical diagnosis Medical research Medicine Mutant Proteins - genetics Mutation Mutation - genetics Neoplasm Proteins - chemistry Neoplasm Proteins - genetics NF-κB protein Pathology Pathways Protein Structure, Tertiary Proteins Receptors Reproducibility of Results Signaling T cell receptors Target recognition Tumors Working groups
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