Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase

The Werner protein (WRNp), a member of the RecQ helicase family, is strongly associated with the nucleolus, as is nucleolin (NCL), an important nucleolar constituent protein. Both WRNp and NCL respond to the effects of DNA damaging agents. Therefore, we have investigated if these nuclear proteins in...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e35229
Hauptverfasser:	Indig, Fred E, Rybanska, Ivana, Karmakar, Parimal, Devulapalli, Chakravarty, Fu, Haiqing, Carrier, France, Bohr, Vilhelm A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aphidicolin Biology Camptothecin Camptothecin - pharmacology Cancer Cell Line Cell Nucleolus - drug effects Cell Nucleolus - metabolism Damage Data processing Deoxyribonucleic acid Dissociation DNA DNA damage DNA helicase DNA repair DNA structure DNA topoisomerase Electrophoretic mobility Exodeoxyribonucleases - antagonists & inhibitors Exodeoxyribonucleases - chemistry Exodeoxyribonucleases - metabolism Exonuclease Fibroblasts G-Quadruplexes - drug effects Gerontology Humans Hydroxyurea Immunoglobulins Immunoprecipitation Ionizing radiation Laboratories Localization Medical research Metabolism Mitomycin Mitomycin C Nucleoli Nucleolin Oligonucleotides Oligonucleotides - metabolism Phosphoproteins - chemistry Phosphoproteins - metabolism Phosphorylation Protein binding Protein Binding - drug effects Protein Interaction Mapping Protein Structure, Tertiary Protein Transport - drug effects Proteins Recombinant Fusion Proteins - metabolism RecQ Helicases - antagonists & inhibitors RecQ Helicases - chemistry RecQ Helicases - metabolism RecQ protein Repair Ribonucleic acid RNA RNA-binding protein RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism Rodents Saccharomyces cerevisiae Substrate Specificity - drug effects Transcription factors Unwinding Werner Syndrome Helicase Yang, Cindy Yeast
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