Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus

Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most frequent genetic event in the early stages of non-small cell lung cancer (NSCLC). This locus has been found by multiple genome wide association st...

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Veröffentlicht in:	PloS one 2012-06, Vol.7 (6), p.e36116
Hauptverfasser:	James, Michael A, Wen, Weidong, Wang, Yian, Byers, Lauren A, Heymach, John V, Coombes, Kevin R, Girard, Luc, Minna, John, You, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenocarcinoma - genetics Adenocarcinoma of Lung Apoptosis Apoptosis - drug effects Apoptosis - genetics Bcl-x protein bcl-X Protein - metabolism Biology Biomarkers Biotechnology Camptothecin Cancer Cancer genetics Cancer research Cell Line, Tumor Cervical cancer Chemotherapy Chromosome 5 Chromosomes, Human, Pair 5 - genetics Cisplatin Cleft lip/palate Copy number Cytotoxicity DNA Damage - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects Genetic Association Studies Genetic Loci - genetics Genetic Predisposition to Disease Genome-wide association studies Genomes Genotoxicity Health aspects Health risks Humans Killing Kinases Loci Lung cancer Lung diseases Lung Neoplasms - genetics Medicine Membrane Proteins - genetics Membrane Proteins - metabolism Mutagens - toxicity Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Non-small cell lung cancer Non-small cell lung carcinoma Ovarian cancer Pharmacology Proteins Risk Factors Smoking Tissues Toxicology Tumor cell lines Tumor cells Tumorigenesis Tumors
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