Inhibition of EP4 signaling attenuates aortic aneurysm formation

Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is currently available. Activation of prostaglandin E(2) (PGE(2)) is known to increase the expression of matrix metalloproteinase (MMP) and the release of inflammatory cytokines, and ma...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36724
Hauptverfasser:	Yokoyama, Utako, Ishiwata, Ryo, Jin, Mei-Hua, Kato, Yuko, Suzuki, Orie, Jin, Huiling, Ichikawa, Yasuhiro, Kumagaya, Syun, Katayama, Yuzo, Fujita, Takayuki, Okumura, Satoshi, Sato, Motohiko, Sugimoto, Yukihiko, Aoki, Hiroki, Suzuki, Shinichi, Masuda, Munetaka, Minamisawa, Susumu, Ishikawa, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Activation Aged Aged, 80 and over Aneurysm Aneurysms Angiotensin Angiotensin II Angiotensin II - adverse effects Angiotensins Animal models Animal tissues Animals Aorta Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - prevention & control Aortic aneurysms Apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - metabolism Attenuation Biology Bone marrow Calcium chloride Cell Line Chemokines Cytokines Degradation Disease Models, Animal Enzyme Activation - drug effects Enzymes EP4 protein Extracellular matrix Female Gelatinase A Gelatinase B Gene Deletion Geriatrics Humans Inflammation Inhibition Interleukin Interleukin 6 Interleukin-6 - biosynthesis Interleukins Life sciences Lymphoma Macrophages Male Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors Medical treatment Medicine Metalloproteinase Mice Mice, Knockout Middle Aged Monocyte chemoattractant protein 1 Muscles Myocytes, Smooth Muscle - metabolism Naphthalenes - pharmacology Older people Oral administration Pharmaceutical industry Pharmacology Phenylbutyrates - pharmacology Prostaglandin E2 Protein folding Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors Receptors, Prostaglandin E, EP4 Subtype - genetics Receptors, Prostaglandin E, EP4 Subtype - metabolism Signal Transduction - drug effects Signaling Smooth muscle Stimulation Studies Surgery Tissue Culture Techniques University graduates Up-Regulation - genetics
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